由创伤、炎症、肿瘤和各种​​其他因素引起的骨缺损影响健康和生活质量。尽管自体骨移植是治疗骨缺损的金标准，但它存在供体部位限制、手术时间长和潜在并发症等缺点，因此需要开发替代骨组织工程材料。在这项研究中，我们使用3D打印技术来制造具有优异生物相容性和机械性能的多孔钛植入物。将海藻酸钠（SA）和锶离子（Sr2）整合到矿化胶原基质（MC）中，开发出具有高机械强度和持续金属离子释放能力的锶功能化海藻酸盐矿化胶原水凝胶（SAM）。 SAM 被无缝地融入 3D 打印钛支架的多孔结构中，建立了一种新型的有机-无机生物活性界面。该复合系统在体外表现出高生物相容性，并增加了对成骨分化和血管生成重要的基因的表达。在股骨缺损的兔子模型中，钛植入物有效促进了其表面的骨和血管再生，凸显了它们在促进骨-植入物整合方面的潜力。版权所有 © 2024。由 Elsevier B.V. 出版。

Bone defects, resulting from trauma, inflammation, tumors, and various other factors, affect both health and quality of life. Although autologous bone transplantation is the gold-standard treatment for bone defects, it has disadvantages such as donor site limitations, prolonged surgical durations, and potential complications, necessitating the development of alternative bone tissue engineering materials. In this study, we used 3D printing technology to fabricate porous titanium implants characterized by superior biocompatibility and mechanical properties. Sodium alginate (SA) and strontium ions (Sr2+) were integrated into mineralized collagen matrices (MCs) to develop strontium-functionalized alginate-mineralized collagen hydrogels (SAMs) with high mechanical strength and sustained metal ion release ability. SAMs were seamlessly incorporated into the porous structures of 3D-printed titanium scaffolds, establishing a novel organic-inorganic bioactive interface. This composite system exhibited high biocompatibility in vitro and increased the expression of genes important for osteogenic differentiation and angiogenesis. In a rabbit model of femoral defect, the titanium implants effectively promoted bone and vascular regeneration on their surface, highlighting their potential in facilitating bone-implant integration.Copyright © 2024. Published by Elsevier B.V.