来自 Tithonia diversifolia 的倍半萜内酯具有铁死亡诱导活性。
Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities.
发表日期：2024 Jul 10
作者：
Ao-Xue Ding, Yi-Ming Shan, Chen-Yue Li, Guo-Qing Qin, Tong Chen, Qing Wang, Xiang-Gang Hu, Peng-Ju Guo, Hai-Jun Yu, Wen-Qiong Wang, Li-Jiang Xuan
来源：
PHYTOCHEMISTRY
摘要：
从 Tithonia diversifolia (Hemsl.) A. Gray 的地上部分分离出八种以前未描述的倍半萜内酯 (1-8) 以及六种已知的倍半萜内酯 (9-14)。使用 HRMS、NMR 光谱、旋光度测量、X 射线晶体学和 ECD 阐明了这些化合物的绝对构型。其中倍半萜内酯2-4具有独特的碳骨架，具有罕见的C-3/C-4开环结构。化合物 1 和 8 通过促进脂质 ROS 的产生，对 CT26 鼠结肠癌细胞显示出中等的抑制作用，突出了它们作为铁死亡诱导剂的潜力。版权所有 © 2024。由 Elsevier Ltd 出版。
Eight previously undescribed sesquiterpene lactones (1-8), together with six known ones (9-14) were isolated from the aerial parts of Tithonia diversifolia (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones 2-4 share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds 1 and 8 showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers.Copyright © 2024. Published by Elsevier Ltd.