高灵敏度和特异性的生物标志物检测对于癌症的诊断和治疗具有极其重要的意义。在此，我们开发了基于异质结的具有低背景噪声和高灵敏度的鲁棒光电化学（PEC）生物传感器，它可以通过限制光生电子空穴对的复合并成功扩大光吸收范围来提高半导体光电性能。甲胎蛋白 (AFP) 被用作目标模型来检查所设计的 PEC 生物传感器的分析性能。 ZnO/Cs3MnBr5异质膜具有均匀的多孔结构和大表面积，增强了电子转移和生物分子固定，并显着提高了光电流响应。在最佳条件下，设计的PEC生物传感器表现出0.01-500 ng/mL的线性检测范围和12 pg/mL的检测限。此外，该PEC生物传感器在检测人血清样本时表现良好，表现出良好的重复性、时间稳定性和特异性，在未来生物学和临床研究中显示出癌症标志物检测的巨大潜力。

Highly sensitive and specific biomarker detection is of outstanding importance for the diagnosis and treatment of cancers. Herein, we developed robust photoelectrochemical (PEC) biosensors with low background noise and high sensitivity based on a heterojunction, which can improve semiconductor photoelectric properties by limiting the recombination of photogenerated electron-hole pairs and successfully widening the range of light absorption. Alpha-fetoprotein (AFP) was used as a target model to examine the analytical performances of the designed PEC biosensors. ZnO/Cs3MnBr5 heterogeneous film with a uniform porous structure and large surface area enhanced electron transfer and biomolecule immobilization, and significantly increased the photocurrent response. Under the optimal conditions, the designed PEC biosensor exhibited a linear detection range of 0.01-500 ng/mL and a detection limit of 12 pg/mL. In addition, this PEC biosensor performed well when testing human serum samples and exhibited good repeatability, stability over time, and specificity, showing enormous potential for the detection of cancer markers in future biological and clinical research.