新合成的 7-氯-4-氨基喹啉-苯并咪唑杂化物通过核磁共振和元素分析进行​​了表征。测试了化合物对非肿瘤细胞系 MRC-5（人胎肺成纤维细胞）和癌（HeLa 和 CaCo-2）、白血病和淋巴瘤（Hut78、THP-1 和 HL-60）生长的影响） 细胞系。获得的结果以实现 50% 细胞生长抑制的浓度（IC50 值）表示，表明测试化合物对细胞生长的影响不同，具体取决于细胞系和所用剂量（IC50 范围为 0.2 至 >100 µM） ）。此外，还针对两种恶性疟原虫菌株（Pf3D7 和 PfDd2）评估了这些杂种的抗疟原虫活性。测试的化合物在纳摩尔浓度下对两种菌株都显示出有效的抗疟原虫活性。定量构效关系 (QSAR) 分析得出了针对 3D7 菌株（R2 = 0.886；Rext2 = 0.937；F = 41.589）和 Dd2 菌株（R2 = 0.859；Rext2 = 0.878；F = 32.525）的抗疟原虫活性的预测模型。恶性疟原虫。 QSAR 模型确定了这些抗疟原虫活性有利作用的结构特征。

Newly synthesized 7-chloro-4-aminoquinoline-benzimidazole hybrids were characterized by NMR and elemental analysis. Compounds were tested for their effects on the growth of the non-tumor cell line MRC-5 (human fetal lung fibroblasts) and carcinoma (HeLa and CaCo-2), leukemia, and lymphoma (Hut78, THP-1, and HL-60) cell lines. The obtained results, expressed as the concentration at which 50% inhibition of cell growth is achieved (IC50 value), show that the tested compounds affect cell growth differently depending on the cell line and the applied dose (IC50 ranged from 0.2 to >100 µM). Also, the antiplasmodial activity of these hybrids was evaluated against two P. falciparum strains (Pf3D7 and PfDd2). The tested compounds showed potent antiplasmodial activity, against both strains, at nanomolar concentrations. Quantitative structure-activity relationship (QSAR) analysis resulted in predictive models for antiplasmodial activity against the 3D7 strain (R2 = 0.886; Rext2 = 0.937; F = 41.589) and Dd2 strain (R2 = 0.859; Rext2 = 0.878; F = 32.525) of P. falciparum. QSAR models identified the structural features of these favorable effects on antiplasmodial activities.