维生素C是一种通过饮食引入的水溶性维生素，具有抗炎、免疫调节和抗氧化活性。如今，这种维生素已被纳入许多炎症性疾病的治疗中。然而，越来越多的证据表明可能用于治疗自身免疫和肿瘤疾病。我们回顾了文献，以更深入地探讨使用维生素 C 治疗此类病理的基本原理。文献中有大量证据表明补充维生素 C 对治疗系统性红斑狼疮 (SLE) 和类风湿关节炎 (RA) 等自身免疫性疾病以及肿瘤，特别是血液肿瘤疾病具有有益作用。维生素 C 整合调节细胞因子微环境，调节对自身抗原和癌细胞的免疫反应，并调节氧化应激。此外，整合治疗对治疗血液肿瘤的化疗、电离辐射和靶向治疗具有增强的效果。未来，综合治疗将在预防病理和作为标准治疗的辅助方面发挥越来越重要的作用。

Vitamin C is a water-soluble vitamin introduced through the diet with anti-inflammatory, immunoregulatory, and antioxidant activities. Today, this vitamin is integrated into the treatment of many inflammatory pathologies. However, there is increasing evidence of possible use in treating autoimmune and neoplastic diseases. We reviewed the literature to delve deeper into the rationale for using vitamin C in treating this type of pathology. There is much evidence in the literature regarding the beneficial effects of vitamin C supplementation for treating autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) and neoplasms, particularly hematological neoplastic diseases. Vitamin C integration regulates the cytokines microenvironment, modulates immune response to autoantigens and cancer cells, and regulates oxidative stress. Moreover, integration therapy has an enhanced effect on chemotherapies, ionizing radiation, and target therapy used in treating hematological neoplasm. In the future, integrative therapy will have an increasingly important role in preventing pathologies and as an adjuvant to standard treatments.