鞍区肿块是常见的颅内肿瘤。它们的临床表现差异很大，包括头痛。我们的目的是确定鞍区肿瘤患者头痛的患病率和特征是否与一般人群不同，并研究肿瘤切除对这种症状的影响。我们在一个三级中心进行了一项前瞻性对照研究，纳入了 57 名患者，接受经蝶鞍区肿块切除术（53% 女性，平均年龄 53.5±16.4 岁）及其 29 名伴侣（对照组；45% 女性，平均年龄 54.8±14.9 岁）。结果指标为术前 1 个月和术后 3 个月神经外科随访时头痛的患病率、特征和影响。术前，患者定期头痛（每月≥1 次）的患病率高于对照组（54% vs 17%）。 %，p < 0.001），并且患者在头痛影响问卷中得分较高（所有 p ≤ 0.01）。术后随访时，两组头痛发生率均下降，但患者常规头痛频率和影响的下降幅度大于对照组，且组间不存在差异。超过一半的鞍区肿瘤患者至少患有以下疾病：每月一次的头痛，与对照组相比，定期头痛的发生率和影响都更高。术后随访时，与对照组相比，患者的头痛症状明显减少，表明肿瘤切除除了时间因素之外还有额外的效果。© 2024 作者。内分泌学、糖尿病

Sellar masses are common intracranial neoplasms. Their clinical manifestations vary widely and include headache. We aimed to determine whether the prevalence and characteristics of headache in patients with sellar tumours differ from the general population and to investigate the effect of tumour resection on this complaint.We performed a prospective, controlled study in a single tertiary centre and included 57 patients that underwent transsphenoidal resection for a sellar mass (53% females, mean age 53.5 ± 16.4) and 29 of their partners (controls; 45% females, mean age 54.8 ± 14.9). Outcome measures were prevalence, characteristics and impact of headache 1 month preoperatively and at neurosurgical follow-up 3 months postoperatively.Preoperatively, the prevalence of regular headache (≥1 time per month) was higher in patients than in controls (54% vs. 17%, p < 0.001), and patients scored higher on headache impact questionnaires (all p ≤ 0.01). At postoperative follow-up, headache prevalence decreased in both groups, but the decrease in regular headache frequency and impact was larger in patients than in controls, and no between-group differences remained.More than half of patients with sellar tumours suffer from at least once-monthly headaches, and both regular headache occurrence and impact are higher compared with controls. The more pronounced decrease in headache complaints in patients versus controls at postoperative follow-up suggests an additional effect of tumour resection next to the factor time.© 2024 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.