淋巴瘤被认为是狗蛋白尿的可能原因。然而，关于蛋白尿对患有淋巴瘤的狗的潜在重要性的信息是有限的。为了确定诊断时蛋白尿的存在是否与患有淋巴瘤的狗的中位生存时间相关，以及淋巴瘤分期（I-V）或类型（B vs T）是否与与蛋白尿的存在相关。2008 年至 2020 年间，86 只客户拥有的狗被新诊断为淋巴瘤。这是一项回顾性横断面研究，根据试纸尿蛋白（蛋白质≥30）将狗分为蛋白尿组或非蛋白尿组mg/dL 归类为蛋白尿）或试纸蛋白与尿比重的比率（比率≥1.5 归类为蛋白尿）。狗因以下原因被排除：（1）2个月内接受过糖皮质激素、抗肿瘤或抗蛋白尿疗法，（2）诊断出皮质醇增多症或肾淋巴瘤，（3）活动性尿沉渣，或（4）尿液pH值> 8。生存分析采用 Kaplan-Meier 估计器和对数秩检验。通过尿液试纸分类的蛋白尿和非蛋白尿狗之间的中位生存期存在显着差异（245 天 [91, 399] 与 335 天 [214, 456]；P = .03) 或 UP : USG (237 天 [158, 306] vs 304 天 [173, 434]；P = .03)。不同阶段（I-V）或类型（B 和 T）之间的蛋白尿患病率没有差异。蛋白尿似乎与新诊断患有淋巴瘤的狗的生存时间呈负相关。© 2024 作者。 《兽医内科杂志》由 Wiley periodicals LLC 代表美国兽医内科学院出版。

Lymphoma has been implicated as a possible cause of proteinuria in dogs. However, information about the potential importance of proteinuria in dogs with lymphoma is limited.To determine if the presence of proteinuria at diagnosis was associated with median survival times in dogs with lymphoma and if lymphoma stage (I-V) or type (B vs T) were associated with the presence of proteinuria.Eighty-six client-owned dogs with a new diagnosis of lymphoma between 2008 and 2020.This was a retrospective cross-sectional study with dogs divided into proteinuric or nonproteinuric groups based on dipstick urine protein (protein ≥30 mg/dL classified as proteinuric) or a ratio of dipstick protein to urine specific gravity (ratio ≥1.5 classified as proteinuric). Dogs were excluded for: (1) treatment within 2 months with glucocorticoid, anti-neoplastic, or anti-proteinuric therapies, (2) diagnosed hypercortisolism or renal lymphoma, (3) active urine sediment, or (4) urine pH >8. Survival analysis utilized a Kaplan-Meier estimator and log-rank testing.There was a significant difference in median survival between proteinuric and nonproteinuric dogs classified by urine dipstick (245 days [91, 399] vs 335 days [214, 456]; P = .03) or UP : USG (237 days [158, 306] vs 304 days [173, 434]; P = .03). No difference in prevalence of proteinuria was identified between stages (I-V) or types (B and T).Proteinuria appears to be negatively associated with survival time in dogs newly diagnosed with lymphoma.© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.