尽管年龄较小与辅助内分泌治疗（ET）的坚持呈负相关，但导致不坚持的因素仍知之甚少。我们评估了与不坚持接受 ET 相关的因素，并描述了患有激素受体阳性乳腺癌 (BC) 的年轻女性（≤40 岁）的 5 年生活质量 (QoL) 轨迹和症状。我们检索了临床数据“帮助我们自己，帮助他人：年轻女性 BC 研究”（IBCSG 43-09 HOHO）欧洲队列的医疗年度记录中的特征和非持久性。女性在基线上完成调查，三年内每半年完成一次调查，之后七年每年完成一次调查。数据收集包括社会人口统计信息、癌症康复评估系统简表评估的生活质量方面以及乳腺癌预防试验症状量表评估的症状。应用 Cox 回归模型来识别与不坚持相关的因素。5 年内中断 ET 的累积风险为 27.7%（95% CI，21.5-35.2）。生活质量子量表分数在五年内保持稳定，身体子量表略有改善。随着时间的推移，潮热减少 (p < 0.001)，而阴道问题则加剧 (p < 0.001)。已婚但没有孩子以及与医疗团队互动和沟通有困难与不坚持有显着相关。与有伴侣的无孩子妇女讨论怀孕的愿望并与医疗团队建立良好的关系可能对于解决不坚持的问题很重要。年轻的不列颠哥伦比亚省幸存者。由于最近的数据表明暂停 ET 受孕的安全性，这种方法可能是未来限制非持续性的合理选择。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Although younger age has been negatively associated with persistence to adjuvant endocrine therapy (ET), factors contributing to non-persistence remain poorly understood. We assessed factors associated with non-persistence to ET and described the 5-year trajectories of quality of life (QoL) and symptoms in young women (≤40 years) with hormone receptor-positive breast cancer (BC).We retrieved data on clinical characteristics and non-persistence from the medical annual records in the European cohort of the "Helping Ourselves, Helping Others: The Young Women's BC Study" (IBCSG 43-09 HOHO). Women completed surveys at baseline, biannually for three years, and annually for another seven years. Data collection included sociodemographic information, QoL aspects assessed by the Cancer Rehabilitation Evaluation System-Short Form and symptoms assessed by the Breast Cancer Prevention Trial symptom scales. Cox regression models were applied to identify factors associated with non-persistence.The cumulative risk of interrupting ET within 5 years was 27.7 % (95 % CI, 21.5-35.2). The QoL subscale scores remained stable over 5 years, with slight improvements in the physical subscale. Hot flashes decreased (p < 0.001), while vaginal problems intensified (p < 0.001) over time. Being married without children and having difficulties interacting and communicating with the medical team were significantly associated with non-persistence.Discussing the desire to conceive with partnered childless women and establishing a good relationship with the medical team may be important in addressing the non-persistence in young BC survivors. As recent data suggests the safety of pausing ET to conceive, this approach may be a reasonable future option to limit non-persistence.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.