使用孟德尔随机化 (MR) 方法测试三种泌尿系统癌症和八种泌尿系统/生殖疾病的血糖敏感性。应用双样本 MR 来研究三种血糖特征（II 型糖尿病、空腹血糖和糖化血红蛋白）的因果作用。 HbA1c)) 十一种泌尿/生殖疾病（肾癌、膀胱癌、前列腺癌、肾/输尿管结石、尿失禁、良性前列腺增生、勃起功能障碍、女性不孕症、男性不育症、精子异常和多囊卵巢综合征）。我们进行了进一步的多变量 MR (MVMR) 和中介分析来调查相关性。在所有 11 种疾病中，II 型糖尿病与勃起功能障碍呈正相关，这在两个队列中都是稳定的[比值比 (OR)：1.59，95% 置信度区间 (CI)：1.15-2.20，FinnGen Biobank 的 P = 0.005，OR：1.14，95% CI：1.08-1.21，其他队列的 P < 0.001]。此外，II型糖尿病与男性不育呈负相关（OR：0.57，95％CI：0.39-0.84，P = 0.005）。此外，所有三个血糖特征均被观察到与多囊卵巢综合征呈正相关（OR：2.36，95％CI：1.16-4.76，每mmol/L空腹血糖P = 0.017；OR：3.04，95％CI：1.10 HbA1c 百分比为 -8.39，P = 0.032；OR：1.21，95% CI：1.00-1.46，II 型糖尿病 P = 0.046）。中介分析证实了II型糖尿病对这些疾病的影响。勃起功能障碍、男性不育症和多囊卵巢综合征存在血糖易感性。我们无法得出其他泌尿系统/生殖疾病中稳定的血糖敏感性的结论。© 2024。作者。

To test the glycemic susceptibility in three urological cancers and eight urological/reproductive diseases using the Mendelian randomization (MR) method.Two-sample MR was applied to investigate the causal role of three glycemic traits (type II diabetes, fasting glucose and glycated hemoglobin (HbA1c)) in eleven urological/reproductive diseases (kidney cancer, bladder cancer, prostate cancer, kidney/ureter stone, urinary incontinence, benign prostatic hyperplasia, erectile dysfunction, female infertility, male infertility, abnormal spermatozoa and polycystic ovary syndrome). Further multivariate MR (MVMR) and mediating analysis were performed to investigate the associations.Among all the 11 diseases, type II diabetes was positively associated with erectile dysfunction, which was stable across both cohorts [odds ratio (OR): 1.59, 95% confidence interval (CI): 1.15-2.20, P = 0.005 for FinnGen Biobank and OR: 1.14, 95% CI: 1.08-1.21, P < 0.001 for the other cohort]. Also, type II diabetes was negatively associated with male infertility (OR: 0.57, 95% CI: 0.39-0.84, P = 0.005). In addition, all three glycemic traits were observed to be positively associated with polycystic ovary syndrome (OR: 2.36, 95% CI: 1.16-4.76, P = 0.017 for fasting glucose per mmol/L; OR: 3.04, 95% CI: 1.10-8.39, P = 0.032 for HbA1c per percentage; and OR: 1.21, 95% CI: 1.00-1.46, P = 0.046 for type II diabetes). Mediating analysis confirmed the effect of type II diabetes on these diseases.There existed glycemic susceptibility in erectile dysfunction, male infertility and polycystic ovary syndrome. We could not conclude stable glycemic susceptibility in other urological/reproductive diseases.© 2024. The Author(s).