研究动态
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日本低剂量辐射研究规划和行动网络(PLANET)的建立和活动:2016-2023 年。

Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016-2023.

发表日期:2024 Jul 15
作者: Yutaka Yamada, Tatsuhiko Imaoka, Toshiyasu Iwasaki, Junya Kobayashi, Munechika Misumi, Kazuo Sakai, Takashi Sugihara, Keiji Suzuki, Hiroshi Tauchi, Hiroshi Yasuda, Shinji Yoshinaga, Megumi Sasatani, Satoshi Tanaka, Kazutaka Doi, Masanori Tomita, Daisuke Iizuka, Shizuko Kakinuma, Michiya Sasaki, Michiaki Kai
来源: Stem Cell Research & Therapy

摘要:

日本低剂量辐射研究规划和行动网络 (PLANET) 于 2017 年成立,以满足全日本专家网络的需​​求。它作为一个学术平台,提出策略并促进合作,以改进低剂量和低剂量率电离辐射健康风险的定量估计。 PLANET 成立了第 1 工作组(动物实验中的剂量率效应),以巩固动物实验中剂量率对致癌作用的影响的研究结果。考虑到该领域的国际趋势以及日本的情况,PLANET更新了2023年日本低剂量辐射研究的优先研究领域,包括(i)低剂量和低剂量率辐射风险的表征,(ii) ) 辐射风险个体化要考虑的因素,(iii) 低剂量和低剂量率辐射效应的生物学机制,以及 (iv) 流行病学和生物学的整合。在此背景下,PLANET 成立了第 2 工作组(辐射风险研究的剂量和剂量率绘图),以确定已报告的对不同终点的可观察影响的剂量和剂量率范围;第 3 工作组(物种和器官特异性剂量率效应)考虑干细胞动力学在不同物种和器官放射性致癌作用中的相关性;第四工作组(辐射相关致癌研究图谱)整理相关研究,包括非诱变效应的研究,并确定优先研究领域。这些 PLANET 活动将用于改进风险评估,并有助于修订国际放射防护委员会的下一个主要建议。© 作者 2024。由牛津大学出版社代表日本辐射研究出版学会和日本放射肿瘤学会。
The Planning and Acting Network for Low Dose Radiation Research in Japan (PLANET) was established in 2017 in response to the need for an all-Japan network of experts. It serves as an academic platform to propose strategies and facilitate collaboration to improve quantitative estimation of health risks from ionizing radiation at low-doses and low-dose-rates. PLANET established Working Group 1 (Dose-Rate Effects in Animal Experiments) to consolidate findings from animal experiments on dose-rate effects in carcinogenesis. Considering international trends in this field as well as the situation in Japan, PLANET updated its priority research areas for Japanese low-dose radiation research in 2023 to include (i) characterization of low-dose and low-dose-rate radiation risk, (ii) factors to be considered for individualization of radiation risk, (iii) biological mechanisms of low-dose and low-dose-rate radiation effects and (iv) integration of epidemiology and biology. In this context, PLANET established Working Group 2 (Dose and Dose-Rate Mapping for Radiation Risk Studies) to identify the range of doses and dose rates at which observable effects on different endpoints have been reported; Working Group 3 (Species- and Organ-Specific Dose-Rate Effects) to consider the relevance of stem cell dynamics in radiation carcinogenesis of different species and organs; and Working Group 4 (Research Mapping for Radiation-Related Carcinogenesis) to sort out relevant studies, including those on non-mutagenic effects, and to identify priority research areas. These PLANET activities will be used to improve the risk assessment and to contribute to the revision of the next main recommendations of the International Commission on Radiological Protection.© The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.