神经胶质瘤的临床治疗仍相对不成熟。临床上常用的胶质瘤治疗方法是手术结合化疗和放疗，但存在耐药问题。此外，免疫治疗和靶向治疗也存在免疫逃避的问题。代谢疗法的出现为针对这种侵袭性疾病推进更有效和更耐受的疗法提供了巨大的潜力。代谢疗法在分子水平上改变肿瘤细胞的代谢过程，以抑制肿瘤生长和扩散，并为对常规治疗不敏感的神经胶质瘤患者带来更好的结果。而且与常规疗法相比，对正常细胞的影响更小，毒副作用更小，安全性更高。本综述的目的是检查神经胶质瘤整个发展过程中代谢特征的变化，列举当前用于研究肿瘤代谢的方法，并强调神经胶质瘤的代谢重编程途径及其潜在的分子机制。重要的是，它试图阐明胶质母细胞瘤（GBM）治疗的潜在代谢靶点，并根据各种研究总结有效的联合治疗策略。

The clinical treatment of glioma remains relatively immature. Commonly used clinical treatments for gliomas are surgery combined with chemotherapy and radiotherapy, but there is a problem of drug resistance. In addition, immunotherapy and targeted therapies also suffer from the problem of immune evasion. The advent of metabolic therapy holds immense potential for advancing more efficacious and tolerable therapies against this aggressive disease. Metabolic therapy alters the metabolic processes of tumor cells at the molecular level to inhibit tumor growth and spread, and lead to better outcomes for patients with glioma that are insensitive to conventional treatments. Moreover, compared with conventional therapy, it has less impact on normal cells, less toxicity and side effects, and higher safety. The objective of this review is to examine the changes in metabolic characteristics throughout the development of glioma, enumerate the current methodologies employed for studying tumor metabolism, and highlight the metabolic reprogramming pathways of glioma along with their potential molecular mechanisms. Importantly, it seeks to elucidate potential metabolic targets for glioblastoma (GBM) therapy and summarize effective combination treatment strategies based on various studies.