肿瘤微环境是由各种细胞和非细胞成分形成的，这些成分相互作用并形成复杂的相互作用网络。这些细胞成分中的一些还获得分泌表型并在周围环境中释放生长因子、细胞因子、趋化因子等，其能够诱导更多数量的信号传导网络。所有这些相互作用在决定肿瘤发生过程中起着决定性作用。癌症的治疗策略也会对局部微环境产生影响。人们发现，这种相互作用和抗癌疗法会在肿瘤进展过程中诱发更多有害的结果，例如免疫抑制和化疗耐药。因此，了解肿瘤微环境对于应对癌症和化疗耐药至关重要。本综述试图加深对肿瘤微环境和调节肿瘤微环境的不同因素的了解，从而促进肿瘤发生。除了总结肿瘤微环境的主要组成部分以及它们之间发生的各种相互作用之外，它还阐明了现有和潜在的疗法如何对这些动态产生影响。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Tumor microenvironment is formed by various cellular and non-cellular components which interact with one another and form a complex network of interactions. Some of these cellular components also attain a secretory phenotype and release growth factors, cytokines, chemokines etc. in the surroundings which are capable of inducing even greater number of signalling networks. All these interactions play a decisive role in determining the course of tumorigenesis. The treatment strategies against cancer also exert their impact on the local microenvironment. Such interactions and anticancer therapies have been found to induce more deleterious outcomes like immunosuppression and chemoresistance in the process of tumor progression. Hence, understanding the tumor microenvironment is crucial for dealing with cancer and chemoresistance. This review is an attempt to develop some understanding about the tumor microenvironment and different factors which modulate it, thereby contributing to tumorigenesis. Along with summarising the major components of tumor microenvironment and various interactions taking place between them, it also throws some light on how the existing and potential therapies exert their impact on these dynamics.Copyright © 2024 Elsevier B.V. All rights reserved.