作为自由基和内源性效应分子，哺乳动物内源性一氧化氮（NO）主要通过L-精氨酸来源于一氧化氮合酶（NOS）。 NO参与正常的生理反应并提供免疫反应以防止外来细菌的入侵。然而，NO也具有复杂且矛盾的生物学效应。异常的一氧化氮信号传导参与许多疾病的进展，例如癌症。过去几十年来，癌症研究一直与NOS/NO紧密联系在一起，许多预后不良的肿瘤都与NOS的高表达有关。在这篇综述中，我们概述了 NOS/NO 的生物学效应。然后我们重点关注 iNOS/NO 在 HPV、HBV、EBV 和幽门螺杆菌相关肿瘤中的致癌作用。事实上，越来越多的证据表明 iNOS 可用作癌症治疗的潜在治疗靶点。我们强调NOS/NO的促肿瘤作用大于抗肿瘤作用。版权所有©2024 Elsevier B.V.保留所有权利。

As a free radical and endogenous effector molecule, mammalian endogenous nitric oxide (NO) is mainly derived from nitric oxide synthase (NOS) via L-arginine. NO participates in normal physiological reactions and provides immune responses to prevent the invasion of foreign bacteria. However, NO also has complex and contradictory biological effects. Abnormal NO signaling is involved in the progression of many diseases, such as cancer. In the past decades, cancer research has been closely linked with NOS/ NO, and many tumors with poor prognosis are associated with high expression of NOS. In this review, we give a overview of the biological effects of NOS/ NO. Then we focus on the oncogenic role of iNOS/ NO in HPV, HBV, EBV and H. pylori related tumors. In fact, there is growing evidence that iNOS could be used as a potential therapeutic target in cancer therapy. We emphasize that the pro-tumor effect of NOS/ NO is greater than the anti-tumor effect.Copyright © 2024 Elsevier B.V. All rights reserved.