十种新的萘烷聚酮化合物，带状青霉素M (1)、11-epi-8-羟基带状青霉素M (2)、带状青霉素N (3)、8-羟基带状青霉素G (4)、带状青霉素O (5)、带状青霉素P (6)、带状青霉素Q (7)、13-脱羟基苍白青素 A (8)、带状青霉素 R (9) 和带状青霉素 S (10)，以及已知的带状青霉素 G (11) 和 J (12)、苍白青素 A (13) 和 1-乙酰苍白青素 A ( 14)，从与海草大叶藻码头相关的真菌青霉菌 KMM 4679 的乙酸乙酯提取物中分离出来。基于光谱方法建立了分离化合物的结构。带状青霉素 Q (7) 和带状青霉素 S (10) 的绝对构型是使用改进的 Mosher 方法和 ROESY 数据的组合确定的。使用 ECD 光谱的时间依赖性密度泛函理论 (TD-DFT) 计算确定带状青霉素 M (1) 和带状青霉素 N (3) 的绝对构型。提出了化合物 1-14 的生物发生途径。还研究了分离化合物的抗菌、细胞毒性和细胞保护活性。在体外缺氧的 HEK-293 细胞中，在氯化钴 (II) 模拟物中发现了新的带状青霉素 M 和带状青霉素 O 和 R 的显着细胞保护作用。 1-Acetylpallidopenilline A (14) 对人乳腺癌 MCF-7 细胞集落形成具有高度抑制作用，IC50 为 0.66 µM，并且当 MCF-7 细胞用 4-Hydroxytamoxifen 预处理时，其抗癌作用会降低。因此，我们提出 1-乙酰苍白青素 A 作为一种新的异雌激素，具有显着的抗乳腺癌活性。

Ten new decalin polyketides, zosteropenilline M (1), 11-epi-8-hydroxyzosteropenilline M (2), zosteropenilline N (3), 8-hydroxyzosteropenilline G (4), zosteropenilline O (5), zosteropenilline P (6), zosteropenilline Q (7), 13-dehydroxypallidopenilline A (8), zosteropenilline R (9) and zosteropenilline S (10), together with known zosteropenillines G (11) and J (12), pallidopenilline A (13) and 1-acetylpallidopenilline A (14), were isolated from the ethyl acetate extract of the fungus Penicillium yezoense KMM 4679 associated with the seagrass Zostera marina. The structures of isolated compounds were established based on spectroscopic methods. The absolute configurations of zosteropenilline Q (7) and zosteropenilline S (10) were determined using a combination of the modified Mosher's method and ROESY data. The absolute configurations of zosteropenilline M (1) and zosteropenilline N (3) were determined using time-dependent density functional theory (TD-DFT) calculations of the ECD spectra. A biogenetic pathway for compounds 1-14 is proposed. The antimicrobial, cytotoxic and cytoprotective activities of the isolated compounds were also studied. The significant cytoprotective effects of the new zosteropenilline M and zosteropenillines O and R were found in a cobalt chloride (II) mimic in in vitro hypoxia in HEK-293 cells. 1-Acetylpallidopenilline A (14) exhibited high inhibition of human breast cancer MCF-7 cell colony formation with IC50 of 0.66 µM and its anticancer effect was reduced when MCF-7 cells were pretreated with 4-hydroxitamoxifen. Thus, we propose 1-acetylpallidopenilline A as a new xenoestrogen with significant activity against breast cancer.