如今，人类多能干细胞技术在生物医学研究中得到广泛应用，作为早期人类发育的模型，作为功能性人类基因组学的平台，作为疾病、药物筛选和毒理学研究的工具，以及作为细胞疗法的可再生来源。一系列疑难杂症。这场人类多能干细胞革命的基础依赖于广泛学科的进步，包括癌症生物学、辅助生殖、细胞培养和类器官技术、体细胞核移植、灵长类动物胚胎学、单细胞生物学和基因编辑。本综述调查了人类多能性研究的缓慢兴起以及该领域在过去几十年中的指数增长。© 2024 Wiley periodicals LLC。

Today, human pluripotent stem cell technologies find widespread application across biomedical research, as models for early human development, as platforms for functional human genomics, as tools for the study of disease, drug screening and toxicology, and as a renewable source of cellular therapeutics for a range of intractable diseases. The foundations of this human pluripotent stem cell revolution rest on advances in a wide range of disciplines, including cancer biology, assisted reproduction, cell culture and organoid technology, somatic cell nuclear transfer, primate embryology, single-cell biology, and gene editing. This review surveys the slow emergence of the study of human pluripotency and the exponential growth of the field during the past several decades.© 2024 Wiley Periodicals LLC.