癌症是一个全球性的公共卫生问题。天然多糖已被证明可以增强癌症治疗的有效性。西伯利亚黄精 (PS) 几千年来一直被用来治疗多种疾病。 PS含有多种活性成分，包括皂苷、肽、挥发油、多糖和凝集素。许多研究强调了多糖在 PS 中的关键作用。现代研究表明，黄精多糖（PSP）具有多种药理活性，包括免疫调节、抗肿瘤、抗氧化、抗衰老等作用。然而，由于PSP的活性与其复杂的结构特征和其组分的不同分子量密切相关，因此进一步研究其抗肿瘤机制是困难的。因此，本文重点对PSP的研究背景和提取纯化进行综述。还总结了与不同分子量的 PSP 成分抗肿瘤作用机制相关的研究，并提出了 PSP 研究的观点。© 2024。韩国药学会。

Cancer is a global public health problem. Natural polysaccharides have been shown to enhance the effectiveness of cancer treatments. Polygonatum sibiricum (PS) has been used for millennia to treat diverse diseases. PS comprises numerous active constituents, including saponins, peptides, volatile oils, polysaccharides, and lectins. Many studies have highlighted the crucial role of polysaccharides in PS. Modern studies have shown that Polygonatum sibiricum polysaccharide (PSP) exhibits diverse pharmacological activities, including immunomodulatory, antitumor, antioxidant, and anti-aging effects. However, further study of the antitumor mechanisms is difficult because the activities of PSP are closely associated with its complex structural features and the different molecular weights of its components. Therefore, this review focuses on the research background and the extraction and purification of PSP. Studies related to the mechanism of the antitumor effects of PSP constituents of different molecular weights are also summarized, and perspectives on PSP research are presented.© 2024. The Pharmaceutical Society of Korea.