卤化溶剂三氯乙烯 (TCE) 在医药、建筑、消费品和军事领域有多种用途。其中许多用途已因其毒性而被停止或限制，其影响多个靶器官，包括急性、高剂量毒性和慢性、低剂量毒性，还包括多种癌症。美国和国际机构对 TCE 进行了风险和危害评估，并在过去 10-15 年中发布了综合出版物。因此，本文的重点是回顾自那时（即 2014 年）以来最近发布的数据，这些数据澄清了悬而未决的问题或提供了有关 TCE 在几个靶器官中的代谢和毒性机制的更多见解。除了代谢之外，本次综述还重点关注肾脏、肝脏、免疫系统、神经系统、心血管和肺系统、生物标志物的寻找，以及最近对三氯乙烯暴露引起的人类癌症风险和发病率的分析。

The halogenated solvent trichloroethylene (TCE) has had many uses in medicine, construction, consumer products, and the military. Many of these uses have been discontinued or restricted due to its toxicity, which affects multiple target organs and includes both acute, high-dose toxicity and chronic, low-dose toxicity that also encompass several cancers. US and international agencies have conducted risk and hazard assessments for TCE, with comprehensive publications coming out in the last 10-15 years. Accordingly, the focus of this article is to review recently published data since that time (i.e., 2014) that clarify unsettled questions or provide additional insights into the metabolism and mechanisms of toxicity of TCE in several target organs. Besides metabolism, the review focuses on the kidneys, liver, immune system, nervous system, cardiovascular and pulmonary systems, the search for biomarkers, and recent analyses of human cancer risk and incidence from TCE exposure.