类器官正迅速成为理解人类生物学和疾病的公认模型。多能干细胞（PSC）为许多器官提供了起点，并能够对这些器官的胚胎发育和成熟进行建模。 PSC 衍生的类器官的基础可以在优雅的发育研究中找到，这些研究表明，即使从胚胎环境中取出，未成熟细胞也具有经历组织发生的非凡能力。 PSC 类器官是早期方法（例如拟胚体）的演变，通过更精细的控制达到了新的水平，并且在某些情况下超越了组织组织发生到器官样形态发生。但许多类器官的发现并不一定是有计划的，而是好奇心和自由探索的结果。如果我们想看到更多突破性的发现，通过灵活的资助来保护这种以好奇心为主导的研究将非常重要。© 2024 作者。 BioEssays 由 Wiley periodicals LLC 出版。

Organoids are quickly becoming an accepted model for understanding human biology and disease. Pluripotent stem cells (PSC) provide a starting point for many organs and enable modeling of the embryonic development and maturation of such organs. The foundation of PSC-derived organoids can be found in elegant developmental studies demonstrating the remarkable ability of immature cells to undergo histogenesis even when taken out of the embryo context. PSC-organoids are an evolution of earlier methods such as embryoid bodies, taken to a new level with finer control and in some cases going beyond tissue histogenesis to organ-like morphogenesis. But many of the discoveries that led to organoids were not necessarily planned, but rather the result of inquisitive minds with freedom to explore. Protecting such curiosity-led research through flexible funding will be important going forward if we are to see further ground-breaking discoveries.© 2024 The Author(s). BioEssays published by Wiley Periodicals LLC.