胃肠癌（GIC）是威胁全世界人类健康的高度流行的癌症。据报道，Wnt/β-catenin 信号通路在 GIC 的致癌过程中发挥着关键作用。目前，许多针对 GIC 中 Wnt/β-catenin 信号传导的干预措施正在临床试验中进行测试，并取得了可喜的结果。不幸的是，目前还没有临床批准的药物能够有效靶向这一途径。这篇综合综述旨在评估针对 GIC 中 Wnt/β-catenin 信号通路的临床疗法的影响。通过整合生物信息学数据库和过去五年的最新文献数据，我们研究了 GIC 中 Wnt/β-catenin 通路基因和蛋白的异质表达和调控机制。具体来说，我们关注表达模式、突变频率和临床预后，以了解它们对治疗策略的影响。此外，我们还讨论了最近针对该途径的临床试验工作。了解目前正在进行临床研究的抑制剂可能有助于优化基础研究和临床策略。我们希望阐明针对 Wnt/β-catenin 通路的患者精准治疗分层的现状将指导 GIC 精准医疗的未来创新。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Gastrointestinal cancers (GICs) are highly prevalent cancers that threaten human health worldwide. The Wnt/β-catenin signaling pathway has been reported to play a pivotal role in the carcinogenesis of GICs. Numerous interventions targeting the Wnt/β-catenin signaling in GICs are currently being tested in clinical trials with promising results. Unfortunately, there are no clinically approved drugs that effectively target this pathway. This comprehensive review aims to evaluate the impact of clinical therapies targeting the Wnt/β-catenin signaling pathway in GICs. By integrating data from bioinformatics databases and recent literature from the past five years, we examine the heterogeneous expression and regulatory mechanisms of Wnt/β-catenin pathway genes and proteins in GICs. Specifically, we focus on expression patterns, mutation frequencies, and clinical prognoses to understand their implications for treatment strategies. Additionally, we discuss recent clinical trial efforts targeting this pathway. Understanding the inhibitors currently under clinical investigation may help optimize foundational research and clinical strategies. We hope that elucidating the current status of precision therapeutic stratification for patients targeting the Wnt/β-catenin pathway will guide future innovations in precision medicine for GICs.Copyright © 2024 Elsevier Inc. All rights reserved.