天冬氨酸是一种蛋白质非必需氨基酸，在增殖细胞中具有多种重要功能。它主要是由草乙酸通过谷氨酸草乙酸转氨酶 1 或 2（GOT1 或 GOT2）以细胞自主方式产生的，但在某些情况下，它也可以通过 SLC1A3 等转运蛋白或通过巨胞饮作用从微环境中回收。在这篇综述中，我们概述了增殖过程中内源性产生天冬氨酸的生物合成途径。我们讨论了有利于天冬氨酸摄取的条件以及肿瘤和骨髓微环境中外源天冬氨酸的可能来源，大多数可用数据都是在这些微环境中产生的。我们重点介绍天冬氨酸的代谢命运、其各种功能以及针对癌症治疗的天冬氨酸代谢目标的可能方法。版权所有 © 2024。由 Elsevier B.V. 出版。

Aspartate is a proteinogenic non-essential amino acid with several essential functions in proliferating cells. It is mostly produced in a cell autonomous manner from oxalacetate via glutamate oxalacetate transaminases 1 or 2 (GOT1 or GOT2), but in some cases it can also be salvaged from the microenvironment via transporters such as SLC1A3 or by macropinocytosis. In this review we provide an overview of biosynthetic pathways that produce aspartate endogenously during proliferation. We discuss conditions that favor aspartate uptake as well as possible sources of exogenous aspartate in the microenvironment of tumors and bone marrow, where most available data have been generated. We highlight metabolic fates of aspartate, its various functions, and possible approaches to target aspartate metabolism for cancer therapy.Copyright © 2024. Published by Elsevier B.V.