癌症中的 Cullin-RING 连接酶 4：结构、功能和机制。
Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms.
发表日期：2024 Aug 06
作者：
Jingyi Cheng, Xin Bin, Zhangui Tang
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
摘要：
Cullin-RING 连接酶 4 (CRL4) 由于其在多种生物和病理事件，特别是癌症相关事件中的广泛调节作用而引起了极大的关注。 CRL4 通过靶向蛋白酶体降解的各种底物或通过不同的内部成分改变活性来调节癌症进展中的各种事件，从而发挥多效性。在这篇综述中，我们总结了具有多种组成模式的 CRL4 结构，并阐明了 CRL4 在一系列癌症相关事件中的新兴功能和分子机制。版权所有 © 2024。由 Elsevier B.V. 出版。
Cullin-RING ligase 4 (CRL4) has attracted enormous attentions because of its extensive regulatory roles in a wide variety of biological and pathological events, especially cancer-associated events. CRL4 exerts pleiotropic effects by targeting various substrates for proteasomal degradation or changes in activity through different internal compositions to regulate diverse events in cancer progression. In this review, we summarize the structure of CRL4 with manifold compositional modes and clarify the emerging functions and molecular mechanisms of CRL4 in a series of cancer-associated events.Copyright © 2024. Published by Elsevier B.V.