环状RNA (circRNA)是通过前体mRNA反向剪接产生的内源性共价闭合单链RNA。新的证据表明，circRNA 通过调节致癌 STAT3 信号通路促进癌症进展，该信号通路在人类恶性肿瘤中发挥着关键作用。 STAT3 信号相关的 circRNA 表达似乎在多种癌症类型中广泛失调，它们要么充当肿瘤抑制基因，要么充当癌基因。然而，STAT3信号相关的circRNA的生物学效应及其与癌症的关联此前尚未得到系统研究。鉴于此，揭示人类恶性肿瘤中 circRNA 和 STAT3 信号通路之间的相互作用可能为癌症治疗提供一些新的见解。在这篇综述中，我们全面介绍了circRNA在癌症进展中调节STAT3信号传导的分子机制，以及STAT3信号相关的circRNA与其他信号通路之间的串扰。我们还进一步讨论了 circRNA/STAT3 轴在癌症化疗敏感性中的作用。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Circular RNAs (circRNAs) are endogenous covalently closed single-stranded RNAs produced by reverse splicing of pre-mRNA. Emerging evidence suggests that circRNAs contribute to cancer progression by modulating the oncogenic STAT3 signaling pathway, which plays key roles in human malignancies. STAT3 signaling-related circRNAs expression appears to be extensively dysregulated in diverse cancer types, where they function either as tumor suppressors or oncogenes. However, the biological effects of STAT3 signaling-related circRNAs and their associations with cancer have not been systematically studied before. Given this, shedding light on the interaction between circRNAs and STAT3 signaling pathway in human malignancies may provide several novel insights into cancer therapy. In this review, we provide a comprehensive introduction to the molecular mechanisms by which circRNAs regulate STAT3 signaling in cancer progression, and the crosstalk between STAT3 signaling-related circRNAs and other signaling pathways. We also further discuss the role of the circRNA/STAT3 axis in cancer chemotherapy sensitivity.Copyright © 2024 Elsevier B.V. All rights reserved.