本文通过网状传输网络方法（MTNM）研究了单细胞和多细胞模型中正常细胞和癌细胞的电穿孔（EP）。模拟结果表明，在单细胞和多细胞模型中，癌细胞比纳秒脉冲电场（nsPEF）诱导的相应正常细胞经历更快、更显着的局部电刺激。此外，多细胞模型的结果表明，多细胞模型中存在单向邻近效应，即中心的细胞受到影响，其孔隙形成显着减少，但这种效应对于边缘的细胞来说非常弱。系统。这意味着电场选择性地杀死不同分布位置的细胞。这项工作可以为癌细胞 EP 过程的参数选择提供指导。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Electroporation (EP) of the normal cell and cancer cell both in single-cell and multicellular models was investigated by the meshed transport network method (MTNM) in this paper. The simulation results suggest that the cancer cell undergoes faster and more significant local EP than that of the corresponding normal cell induced by nanosecond pulsed electric fields (nsPEFs) both in single-cell and multicellular models. Furthermore, the results of the multicellular model indicate that there is a unidirectional neighboring effect in the multicellular model, meaning that cells at the center are affected and their pore formation is significantly reduced, but this effect is very weak for cells at the edges of the system. This means that the electric field selectively kills cells in different distribution locations. This work can provide guidance for the selection of parameters for the cancer cell EP process.Copyright © 2024 Elsevier B.V. All rights reserved.