90 kDa 热休克蛋白 (HSP90) 是多种客户蛋白折叠、展开、降解和活性所必需的分子伴侣。 HSP90 及其同源共伴侣会受到各种翻译后修饰的影响，其功能后果在癌症中尚未完全了解。细胞内和细胞外 HSP90 家族成员（HSP90α、HSP90β、GRP94 和 TRAP1）通过维持癌症的各种特征来促进癌症，包括细胞死亡抵抗、复制永生、肿瘤免疫、血管生成、侵袭和转移。鉴于 HSP90 在肿瘤进展中的重要性，开发了各种抑制剂和基于 HSP90 的疫苗来治疗癌症。进一步了解 HSP90 在癌症中的功能可能为癌症的治疗提供新的机会和新颖的治疗策略。版权所有 © 2024 Albakova。

The 90-kDa heat shock proteins (HSP90s) are molecular chaperones essential for folding, unfolding, degradation and activity of a wide range of client proteins. HSP90s and their cognate co-chaperones are subject to various post-translational modifications, functional consequences of which are not fully understood in cancer. Intracellular and extracellular HSP90 family members (HSP90α, HSP90β, GRP94 and TRAP1) promote cancer by sustaining various hallmarks of cancer, including cell death resistance, replicative immortality, tumor immunity, angiogenesis, invasion and metastasis. Given the importance of HSP90 in tumor progression, various inhibitors and HSP90-based vaccines were developed for the treatment of cancer. Further understanding of HSP90 functions in cancer may provide new opportunities and novel therapeutic strategies for the treatment of cancer.Copyright © 2024 Albakova.