CAR-T 疗法已成为治疗血液恶性肿瘤患者的一种潜在有效疗法。了解患者对这种治疗方法的独特体验至关重要。这些知识将有助于制定量身定制的护理干预措施，以适应以患者为中心的护理日益重要的趋势。为了检查和综合患者及其家庭护理人员在治疗过程中的经历的定性数据。我们进行了系统回顾和定性元数据分析。合成。符合条件的研究包含成年患者或家庭护理人员对 CAR-T 治疗经验的引用，自 2015 年以来以英文或中文在同行评审期刊上发表。数据来源包括 MEDLINE、CINAHL、Embase、PsycINFO、Web of Science、Scopus、Cochrane 图书馆、CNKI、万方。系统检索共识别出6373篇文章。其中，分析包含 12 份报告，涵盖 11 项独立研究。两名审稿人独立将数据提取到 NVIVO 12.0 中。定性元综合是通过全文逐行编码、将代码组织成描述性主题和发展主题来进行的。定性元综合产生了八个主要主题。患者及其家人护理人员对 CAR-T 治疗历程的值得注意的启示涵盖了各个方面。在接受CAR-T治疗之前，患者缺乏实际选择，在对治疗结果的期望中挣扎，并遇到复杂的情感体验。在 CAR-T 治疗期间或治疗后立即，患者报告了舒适和不舒服的经历。此外，患者强调，对治疗效果和不良反应的担忧加剧了与治疗相关的痛苦。 CAR-T 治疗后，观察到显着的变化，以及家庭康复的负担。此外，我们还发现了导致CAR-T治疗成本高昂的因素。为了确保CAR-T治疗的安全性和可持续性，解决患者体验的生理和心理方面至关重要。有效的沟通和全面的管理受到患者及其护理人员的高度重视。进一步的研究应该探讨减轻患者及其家人负担并制定自我管理教育计划的方法。© 2024。作者。

CAR-T therapy has emerged as a potentially effective treatment for individuals diagnosed with hematologic malignancies. Understanding patients' unique experiences with this therapeutic approach is essential. This knowledge will enable the development of tailored nursing interventions that align with the increasing importance of patient-centered care.To examine and synthesize qualitative data on patients and their family caregivers' experiences during the treatment journey.We conducted a systematic review and qualitative meta-synthesis. Eligible studies contained adult patient or family caregiver quotes about experiences of CAR-T therapy, published in English or Chinese in a peer-reviewed journal since 2015. Data sources included MEDLINE, CINAHL, Embase, PsycINFO, Web of Science, Scopus, Cochrane Library, CNKI, and WanFang.Systematic search yielded 6373 identified articles. Of these, 12 reports were included in the analysis, which covered 11 separate studies. Two reviewers independently extracted data into NVIVO 12.0. Qualitative meta-synthesis was performed through line-by-line coding of full text, organization of codes into descriptive themes, and development themes.The qualitative meta-synthesis yielded eight primary themes. Noteworthy revelations from patients and their family caregivers regarding the CAR-T therapy journey encompassed various aspects. Prior to CAR-T therapy, patients experienced a lack of actual choice, struggled with expectations for treatment outcomes, and encountered intricate emotional experiences. During or immediately after CAR-T therapy, patients reported both comfortable and uncomfortable experiences. Additionally, patients emphasized that concerns regarding treatment efficacy and adverse reactions intensified treatment-related distress. After CAR-T therapy, significant changes were observed, and the burden of home-based rehabilitation. Additionally, we found factors contributed to the high CAR-T therapy cost.To ensure the safety and sustainability of CAR-T therapy, it is crucial to address the physical and psychological aspects of the patient's experience. Effective communication and comprehensive management are highly valued by patients and their caregivers. Further research should investigate ways to reduce burdens and develop self-management education programs for patients and their families.© 2024. The Author(s).