考虑到碳水化合物在为身体提供能量方面发挥着重要作用，并且表现出多种可以预防或刺激癌症的机制，我们假设碳水化合物摄入的质量可能与癌症风险相关，包括肺癌。这项以医院为基础的病例对照研究针对 135 名新诊断的肺癌患者和 237 名年龄和性别匹配的健康住院对照进行。我们使用有效且可靠的 148 项食物频率问卷来收集受试者的饮食摄入量。使用多变量逻辑回归来估计碳水化合物质量指数与肺癌几率之间的关联。调整混杂变量后，高血糖指数似乎是肺癌的一个增加的危险因素[比值比 (OR) = 2.51，95% 置信区间 (CI)：1.28-4.91]。血糖负荷与肺癌之间没有发现统计学上显着的关联（OR = 2.51，95% CI：0.98-6.43）。相比之下，碳水化合物质量指数（OR = 0.23，95% CI：0.11-0.48）和低碳水化合物饮食评分（OR = 0.17，95% CI：0.08-0.36）与肺病风险降低相关。癌症。总之，我们的研究表明，高血糖指数是肺癌的危险因素，而碳水化合物质量指数和低碳水化合物饮食评分是降低肺癌风险的饮食方法。版权所有 © 2024 Wolters Kluwer Health, Inc.版权所有。

Considering that carbohydrates play an important role in supplying the body with energy and exhibit diverse mechanisms that can either prevent or stimulate cancer, we hypothesize that the quality of carbohydrate intake may be associated with cancer risk, including lung cancer. This hospital-based case-control study was conducted on 135 newly diagnosed lung cancer patients, and 237 healthy age- and sex-matched hospitalized controls. We used a valid and reliable 148-item Food Frequency Questionnaire to collect the dietary intake of subjects. Multivariate logistic regression was used to estimate the association between carbohydrate quality indices and the odds of lung cancer. After adjustment for confounding variables, the high glycemic index appears to be an increased risk factor for lung cancer [odds ratio (OR) = 2.51, 95% confidence interval (CI): 1.28-4.91]. No statistically significant association was found between glycemic load and lung cancer (OR = 2.51, 95% CI: 0.98-6.43). In contrast, the carbohydrate quality index (OR = 0.23, 95% CI: 0.11-0.48) and low-carbohydrate diet score (OR = 0.17, 95% CI: 0.08-0.36), were associated with a decrease in the risk of lung cancer. In summary, our study showed that a high glycemic index is a risk factor for lung cancer, however carbohydrate quality index and low-carbohydrate diet score is a dietary approach to reduce the risk of lung cancer.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.