生活方式（在医疗保健中更具体地定义为个人暴露）与其对肥胖和乳腺癌发展的影响之间的相互作用凸显了身体成分和炎症在这些患者中的关键作用。有明确的证据表明，个人和内部暴露组会引发生化、炎症和代谢重编程，这可能有利于体内（例如肌肉）内的异位脂质积累。此外，过多脂肪组织的存在会加剧内部暴露组的这些变化，导致细胞损伤并改变身体成分。了解这些生活方式引起的暴露组改变（例如炎症）与由此产生的身体成分变化之间的联系对于评估与乳腺癌进展和治疗反应的关联至关重要。可以使用多种技术来评估身体成分；目前最常用的方法之一是生物电阻抗分析。该分析提供了包括相位角 (PhA) 在内的参数，通过这些参数可以评估细胞健康和代谢活动。此外，PhA 是营养状况和疾病预后的潜在指标，因为它与癌症患者的生存和生活质量有关。因此，PhA 可用于日常肿瘤学实践中，以实施准确的营养干预，减少肿瘤管理的副作用和并发症，并改善治疗和生存期间的生活质量，甚至对于肥胖或超重的乳腺癌患者也是如此。本综述的目的是分析目前 PhA 在乳腺癌患者中应用的现有信息，及其作为评估炎症反应、识别营养不良和预测生活质量恶化的工具的潜在用途，以便建议作为该组患者营养干预的早期指标。版权所有 © 2024 Elsevier Inc. 保留所有权利。

The interaction between lifestyle--defined more specifically in health care as the personal exposome--and its implications on obesity and breast cancer development highlights the critical role of body composition and inflammation in these patients. There is clear evidence that the personal and internal exposome triggers biochemical, inflammatory, and metabolic reprogramming, which might favor ectopic lipid accumulation within the body, such as muscles. Additionally, the presence of excessive adipose tissue exacerbates these alterations in the internal exposome, resulting in cell damage and modifying body composition. Understanding the nexus between these lifestyle-induced exposome modifications, such as inflammation, and the resultant changes in body composition is crucial to assess the association with breast cancer progression and treatment responses. Various techniques can be used to evaluate body composition; one of those most used currently is bioelectrical impedance analysis. This analysis provides parameters, including phase angle (PhA), by which cellular health and metabolic activity can be assessed. In addition, PhA is a potential indicator of nutritional status and disease prognosis, as it has been linked to survival and quality of life in patients with cancer. Therefore, PhA might be used in daily oncology practice to implement an accurate nutritional intervention, reducing side effects and complications of oncology management, and improving quality of life during treatment and survival, even in patients with breast cancer with obesity or overweight. The aim of this review is to analyze the existing information on the current application of PhA in patients with breast cancer and its potential use as a tool to assess inflammatory response, identify malnutrition, and predict the deterioration of quality of life so that it could be proposed as an early indicator for nutritional interventions in this group of patients.Copyright © 2024 Elsevier Inc. All rights reserved.