已知凝血系统在癌症发展和转移中发挥重要作用，但其确切机制仍不完全清楚。考虑到这一点，我们提供了蛋白酶抑制剂 TFPI-2 对癌症发展和转移影响的最新概述。 TFPI-2 与凝血酶级联相互作用，还采用其他机制来抑制癌症生长和扩散，包括细胞外基质稳定、促进半胱天冬酶介导的细胞凋亡、抑制血管生成和细胞内信号转导。在许多类型的肿瘤中，TFPI-2 表达的下调已得到充分证明，主要是通过启动子甲基化。然而，TFPI-2 在癌症进展中的确切作用以及上调 TFPI-2 表达的可能方法值得进一步研究。重新激活 TFPI-2 的策略可能代表未来抗癌研究和治疗开发的一个有希望的方向。© 2024。作者。

The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms by which it does so remain incompletely understood. With this in mind, we provide an updated overview of the effects of TFPI-2, a protease inhibitor, on cancer development and metastasis. TFPI-2 interacts with the thrombin cascade and also employs other mechanisms to suppress cancer growth and dissemination, which include extracellular matrix stabilization, promotion of caspase-mediated cell apoptosis, inhibition of angiogenesis and transduction of intracellular signals. Down-regulation of TFPI-2 expression is well documented in numerous types of neoplasms, mainly via promoter methylation. However, the exact role of TFPI-2 in cancer progression and possible approaches to up-regulate TFPI-2 expression warrant further studies. Strategies to reactivate TFPI-2 may represent a promising direction for future anticancer studies and therapy development.© 2024. The Author(s).