Klotho 被认为是一种衰老抑制蛋白，与多种过程和信号通路有关。 klotho 的抗炎、抗凋亡、抗氧化和抗肿瘤生物活性扩展了其在神经科学中的应用，并使该蛋白质因其延长寿命的能力而广受欢迎。此外，已经证明，klotho 水平会随着衰老和多种病理，特别是与中枢神经系统 (CNS) 相关的病理而降低。有证据支持这样的观点：klotho 可以成为中枢神经系统疾病（如肌萎缩侧索硬化症、帕金森病、中风和阿尔茨海默病）的关键治疗靶点。回顾文献表明，klotho 表达的上调调节与神经系统疾病中的自噬、氧化应激、炎症、认知和铁死亡相关的各种信号通路。因此，开发提高或恢复克洛索水平的药物或药剂引起了极大的兴趣。在这方面，本综述的目的是收集有关 Klotho 在中枢神经系统疾病中的治疗潜力的授权文件，重点是分子和细胞机制。© 2024。作者获得 Springer Nature B.V. 的独家许可。

Klotho is recognized as an aging-suppressor protein that is implicated in a variety of processes and signaling pathways. The anti-inflammatory, anti-apoptotic, anti-oxidant, and anti-tumor bioactivities of klotho have extended its application in neurosciences and made the protein popular for its lifespan-extending capacity. Furthermore, it has been demonstrated that klotho levels would reduce with aging and numerous pathologies, particularly those related to the central nervous system (CNS). Evidence supports the idea that klotho can be a key therapeutic target in CNS diseases such as amyotrophic lateral sclerosis, Parkinson's disease, stroke, and Alzheimer's disease. Reviewing the literature suggests that the upregulation of klotho expression regulates various signaling pathways related to autophagy, oxidative stress, inflammation, cognition, and ferroptosis in neurological disorders. Therefore, it has been of great interest to develop drugs or agents that boost or restore klotho levels. In this regard, the present review was designed and aimed to gather the delegated documents regarding the therapeutic potential of Klotho in CNS diseases focusing on the molecular and cellular mechanisms.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.