莫斯卡提林是一种来自石斛属的联苄衍生物，传统上用于中药。最近的研究表明，由于其多样化的药理学特性，它具有作为强大抗癌药物的潜力。本综述旨在巩固目前关于莫斯卡提林抗癌机制、结构-活性关系和治疗潜力的研究，以评估其临床应用的可行性。在 PubMed/MedLine、Scopus 和 Web of Science 中进行了文献检索。检索重点是“癌症”、“莫斯卡提林”、“抗癌”、“生物活性”、“石斛”和“药理学特性”。综述了分子机制、临床前和临床疗效以及生物利用度的相关研究。 Moscatilin 对肺癌、乳腺癌、结直肠癌和胰腺癌具有显着的抗癌作用。它通过 JNK/SAPK 途径诱导细胞凋亡，抑制细胞增殖并抑制转移。构效关系研究表明，酚基和二碳桥对其功效至关重要。此外，莫斯卡提林具有良好的生物利用度和良好的安全性，对健康细胞的毒性较低。 Moscatilin 作为抗癌药物具有巨大的潜力，可针对多种癌症进展途径。进一步的临床试验对于确认其在人类中的治疗功效和安全性至关重要。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

Moscatilin, a bibenzyl derivative from the Dendrobium genus, has been traditionally used in Chinese medicine. Recent studies suggest its potential as a powerful anticancer agent due to its diverse pharmacological properties.This review aims to consolidate current research on moscatilin's anticancer mechanisms, structure-activity relationships, and therapeutic potential to assess its viability for clinical use. A literature search was performed in PubMed/MedLine, Scopus, and Web of Science.The search focused on "cancer," "moscatilin," "anticancer," "bioactivity," "dendrobium," and "pharmacological properties." Relevant studies on molecular mechanisms, preclinical and clinical efficacy, and bioavailability were reviewed. Moscatilin exhibits significant anticancer effects in lung, breast, colorectal, and pancreatic cancers. It induces apoptosis via the JNK/SAPK pathway, inhibits cell proliferation, and suppresses metastasis. Structure-activity relationship studies reveal that phenolic groups and a two-carbon bridge are crucial for its efficacy. Additionally, moscatilin shows good bioavailability and a favorable safety profile, with low toxicity to healthy cells. Moscatilin demonstrates considerable potential as an anticancer agent, targeting multiple cancer progression pathways. Further clinical trials are essential to confirm its therapeutic efficacy and safety in humans.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.