无人机的出现彻底改变了我们生活的各个方面，在生物系统领域，分子无人机作为治疗重大疾病的“灵丹妙药”有着巨大的前景。在此，我们介绍了一类独特的氟化大分子两亲物，其设计为水母形状，可作为氟 19 MRI (19F MRI) 和荧光成像 (FLI) 引导的药物输送、状态报告和靶向癌症的示范分子无人机治疗。这些生物相容性分子无人机的功能类似于其机械对应物，可与疏水性药物自主组装，形成均匀的纳米颗粒，促进药物有效输送到细胞中。药物输送的状态可以通过 FLI 和 19F MRI 的聚集诱导发射 (AIE) 进行跟踪。此外，当装载七次甲基花青荧光染料 IR-780 时，这些分子无人机能够对肿瘤进行近红外 (NIR) FL 检测并精确递送光敏剂。同样，当装载阿霉素 (DOX) 时，它们可以通过荧光共振能量转移 (FRET) FL 进行靶向化疗，以实现实时状态更新，从而增强治疗效果。与传统的药物输送系统相比，分子无人机以其简单、结构精确、多功能性和提供即时状态更新的能力而脱颖而出。这项研究提出了能够执行基本无人机功能的原型分子无人机，为开发具有重大生物医学意义的更复杂的分子机器奠定了基础。

The advent of drones has revolutionized various aspects of our lives, and in the realm of biological systems, molecular drones hold immense promise as "magic bullets" for major diseases. Herein, we introduce a unique class of fluorinated macromolecular amphiphiles, designed in the shape of jellyfish, serving as exemplary molecular drones for fluorine-19 MRI (19F MRI) and fluorescence imaging (FLI)-guided drug delivery, status reporting, and targeted cancer therapy. Functioning akin to their mechanical counterparts, these biocompatible molecular drones autonomously assemble with hydrophobic drugs to form uniform nanoparticles, facilitating efficient drug delivery into cells. The status of drug delivery can be tracked through aggregation-induced emission (AIE) of FLI and 19F MRI. Furthermore, when loaded with a heptamethine cyanine fluorescent dye IR-780, these molecular drones enable near-infrared (NIR) FL detection of tumors and precise delivery of the photosensitizer. Similarly, when loaded with doxorubicin (DOX), they enable targeted chemotherapy with fluorescence resonance energy transfer (FRET) FL for real-time status updates, resulting in enhanced therapeutic efficacy. Compared to conventional drug delivery systems, molecular drones stand out for their simplicity, precise structure, versatility, and ability to provide instantaneous status updates. This study presents prototype molecular drones capable of executing fundamental drone functions, laying the groundwork for the development of more sophisticated molecular machines with significant biomedical implications.