槲皮素 (Qc) 具有抗癌特性，例如细胞信号传导、生长抑制、促凋亡、抗增殖和抗氧化作用。在本研究中，我们开发了一种藻酸盐修饰的ZIF-8（Alg@ZIF-8）来增强槲皮素的抗肿瘤功效。

Quercetin (Qc) possesses anti-cancer properties, such as cell signaling, growth suppression, pro-apoptotic, anti-proliferative, and antioxidant effects. In this study, we developed an alginate-modified ZIF-8 (Alg@ZIF-8) to enhance the anti-tumor efficacy of quercetin. Methods: The developed Alg@Qc@ZIF-8 was characterized using SEM, DLS, FTIR, TGA, BET, and XRD. The drug release pattern was evaluated at pH 5.4 and 7.4. The cytotoxicity of nanoparticles was assessed on the 4T1 cell line. Finally, the anti-tumor activity of Alg@Qc@ZIF-8 was evaluated in 4T1 tumor-bearing mice. Results: SEM showed that the nanoparticles were spherical with a diameter of mainly below 50 nm. The DLS showed that the developed nanoparticles' hydrodynamic diameter, zeta potential, and polydispersity index were 154.9 ± 7.25 nm, -23.8 ± 5.33 mV, and 0.381 ± 0.09, respectively. The drug loading capacity was 10.40 ± 0.02 %. Alg@Qc@ZIF-8 exhibited pH sensitivity, releasing more quercetin at pH 5.4 (about 3.62 times) than at pH 7.4 after 24 hours. Furthermore, the IC50 value of Alg@Qc@ZIF-8 on the 4T1 cell line was 2.16 times lower than net Qc. Importantly, in tumor-bearing mice, Alg@Qc@ZIF-8 demonstrated enhanced inhibitory effects on tumor growth and lung metastasis compared to net quercetin. Conclusions: Considering the in vitro and in vivo outcomes, Alg@Qc@ZIF-8 might hold great potential for effective breast cancer management. .© 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.