越来越多的研究表明炎症与抑郁症的发病机制有关。由于并非所有外周炎症水平较高的个体都会出现抑郁症状，因此需要开展额外的工作来确定促进炎症与抑郁症状之间关系的其他因素。鉴于炎症活动水平升高会引起各种情绪变化，本研究检查了情绪清晰度（识别、辨别和表达情绪的类似特征的能力）是否会影响炎症信号传导与并发和表达情绪之间的关联强度。抑郁症的前瞻性症状。社区青少年（N = 225，Mage = 16.63岁）来自一项调查抑郁症发作中性别和种族差异的大型纵向项目，提供血液样本以确定白细胞介素-6（IL-6）的外周水平，基线访视时的肿瘤坏死因子-α (TNF-α) 和 C 反应蛋白 (CRP)，以及情绪清晰度和抑郁症状严重程度的自我报告测量。在基线后约 5 个月的随访中再次评估抑郁症状的严重程度。分层多元回归检测到炎症标志物和情绪清晰度之间对未来抑郁严重程度的显着相互作用，从而控制了基线抑郁症状。具体来说，在情绪清晰度较低的青少年中，较高的 IL-6、CRP 水平和炎症综合评分与未来抑郁严重程度显着相关。这些结果表明，情绪清晰度较低和炎症信号较高可能共同带来未来抑郁的风险。青少年症状的严重程度。改善情绪清晰度的治疗干预措施可能会降低患有轻度外周炎症的青少年出现抑郁症状的风险。版权所有 © 2024。由 Elsevier Inc. 出版。

A growing body of work has implicated inflammation in the pathogenesis of depression. As not all individuals with heightened levels of peripheral inflammation develop symptoms of depression, additional work is needed to identify other factors that catalyze the relationship between inflammation and depressive symptoms. Given that elevated levels of inflammatory activity can induce a variety of emotional changes, the present study examined whether emotional clarity, the trait-like ability to identify, discern, and express one's emotions, influences the strength of the association between inflammatory signaling and concurrent and prospective symptoms of depression.Community adolescents (N=225, Mage = 16.63 years), drawn from a larger longitudinal project investigating sex and racial differences in depression onset, provided blood samples to determine peripheral levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) at a baseline visit, along with self-report measures of emotional clarity and depressive symptom severity. Depressive symptom severity was assessed again at a follow-up visit approximately 5-months after baseline.Hierarchical multiple regressions detected a significant interaction between inflammatory markers and emotional clarity on future depression severity, controlling for baseline depressive symptoms. Specifically, among adolescents with low levels of emotional clarity, higher IL-6, CRP levels, and inflammatory composite scores were significantly associated with greater future depression severity.These results indicate that low emotional clarity and high inflammatory signaling may jointly confer risk for prospective depressive symptom severity among adolescents. Therapeutic interventions that improve emotional clarity may reduce risk of depressive symptoms among adolescents with low-grade peripheral inflammation.Copyright © 2024. Published by Elsevier Inc.