在这篇综述中，作者强调了 IL4 在减轻癌症生长的所有“标志”和对当前免疫疗法的耐药性方面的作用，为其在 GBM 中的作用提供了框架，并为未来的治疗方案提供了指导。本综述围绕 IL4 促进 GBM 中免疫抵抗的六种策略进行组织：(i) 细胞凋亡逃避，(ii) 生长信号的自给自足，(iii) 对抗生长信号不敏感，(iv) 侵袭和转移，(v) 无限的复制潜力，(vi) 持续的血管生成。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

In this review, the author highlights the role of IL4 in mitigating all the "hallmarks" of cancer growth and resistance to current immunotherapy, providing a framework for its role in GBM as well as guideline for future treatment regimens. This review is organized around six strategies by which IL4 contributes to the immune resistance seen in GBM: (i) apoptosis evasion, (ii) self-sufficiency in growth signals, (iii) insensitivity to anti-growth signals, (iv) invasion and metastasis, (v) limitless replicative potential, (vi) sustained angiogenesis.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.