本研究探讨了白塞氏病（BD）与牙周病之间的联系，该病的特点是持续性口腔和生殖器溃疡以及虹膜炎。它检查龈沟液 (GCF) 和唾液中肿瘤坏死因子-α (TNF-α)、白介素-1β (IL-1β) 和一氧化氮 (NO) 的水平。 40 名患有牙龈炎或牙周炎的白塞氏病患者和 47 名患有牙龈炎或牙周炎的白塞氏病患者研究人员对患有牙龈炎或牙周炎但没有 BD 的患者进行了研究。用标准临床指标记录牙周状态。获得GCF和唾液样本。分析 NO、IL-1β 和 TNF-α 水平。记录当前 Behçet 的症状和药物使用情况。与无 BD 患者相比，患有牙龈炎的 BD 患者平均唾液 IL-1β 升高 (p = .045)，平均 NO 水平降低 (p = .000)。相比之下，患有牙周炎的 Behçet 患者的沟液中平均 NO 水平高于未患 BD 的患者 (p = .009)。此外，在白塞氏病患者中，与无血管受累的患者相比，有血管受累的患者唾液 NO 水平较低 (p = .000)。根据我们的研究结果，患有牙龈炎的白塞氏病患者唾液中 IL-1β 水平升高，随着一氧化氮水平的降低，表明口腔炎症反应发生了改变。© 2024。作者。

This study explores the connection between Behçet's disease (BD), characterized by persistent oral and genital ulcers alongside iritis, and periodontal disease. It examines the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO) in gingival crevicular fluid (GCF) and saliva.Forty Behçet's patients with gingivitis or periodontitis and 47 patients with either gingivitis or periodontitis but without BD were studied. Periodontal status was recorded with standard clinical indexes. GCF and saliva samples were obtained. NO, IL-1β and TNF-α levels were analysed. Current Behçet's symptoms and medications usage were recorded.Mean salivary IL-1β was elevated (p = .045), and mean NO level was decreased in BD patients with gingivitis compared to patients without BD (p = .000). In contrast, mean NO level in crevicular fluid was higher in Behçet's patients with periodontitis than in patients without BD (p = .009). Furthermore, among Behçet's patients, those with vascular involvement had lower salivary NO level compared to patients without vascular involvement (p = .000).Based on our findings, the elevated levels of IL-1β in the saliva of Behçet's patients with gingivitis, along with the decreased NO level, indicate an altered inflammatory response in the oral cavity.© 2024. The Author(s).