可溶性环氧化物水解酶（sEH；由 EPHX2 基因编码）是一种 α/β 水解酶折叠蛋白，广泛分布于全身。最近的研究强调，sEH 在多不饱和脂肪酸的代谢中，在多种疾病的发病机制中发挥着重要作用，包括心血管疾病、阿尔茨海默病和肠道相关疾病。本综述讨论了 sEH 在肠道和肠道相关疾病（包括结肠炎、结直肠癌和其他肠道疾病）发展中的作用的最新发现，以及所涉及的潜在潜在机制。© 2024 国际细胞生物学联合会。

The soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) is an α/β hydrolase fold protein that is, widely distributed throughout the body. Recent studies have highlighted that sEH, in the metabolism of polyunsaturated fatty acids, plays a part in the pathogenesis of various diseases, including cardiovascular disease, Alzheimer's disease and intestine-associated disease. This review discusses the current findings on the role of sEH in the development of intestine- and intestine-associated diseases, including colitis, colorectal cancer, and other intestinal diseases, as well as the potential underlying mechanisms involved.© 2024 International Federation for Cell Biology.