本研究旨在对槟榔（BQ）滥用、依赖和槟榔使用障碍（BUD）的测量和患病率进行全面评估，并评估槟榔成瘾对口腔恶性疾病的影响。执行系统评价和荟萃分析的 PRISMA 指南。我们在 PubMed、Web of Science 和 Embase 中检索了截至 2024 年 4 月的相关出版物。这些文章对 BQ 成瘾及其与口腔潜在恶性疾病 (OPMD) 和口腔癌的关系进行了评估。南亚、东南亚和东亚 BQ 滥用、依赖和 BUD 的患病率在 0.8%-46.3%、0.4% 之间变化分别为-43.5%和4.7%-39.2%。在 BQ 咀嚼者中，这些疾病的相应比例范围为 40.5%-99.6%、20.9%-99.6% 和 55.2%-99.3%。与 BQ 滥用、依赖和 BUD 相关的 OPMD 合并风险分别为 16.3、18.7 和 9.6-35.5。轻度、中度和重度 BUD 患口腔癌的风险分别为 8.5、8.2 和 42.3。BUD 介导 BQ 使用与口腔恶性疾病风险增加之间的联系。解决和治疗 BQ 成瘾是全面 OPMD 和口腔癌预防和干预计划的重要组成部分，该计划超出了简单的戒烟努力。© 2024 John Wiley

This study aimed to provide a comprehensive assessment of the measurement and prevalence of betel-quid (BQ) abuse, dependence, and BQ use disorder (BUD), as well as to evaluate the impact of BQ addiction on oral malignant diseases.We used the PRISMA guidelines to perform a systematic review and meta-analysis. We searched for relevant publications up to April 2024 in PubMed, Web of Science, and Embase. The articles were evaluated for BQ addiction and its relationship with oral potentially malignant disorders (OPMD) and oral cancer.The prevalence of BQ abuse, dependence, and BUD in South, Southeast, and East Asia varied between 0.8%-46.3%, 0.4%-43.5%, and 4.7%-39.2%, respectively. Among BQ chewers, the corresponding proportions of these disorders ranged from 40.5%-99.6%, 20.9%-99.6%, and 55.2%-99.3%. The pooled risks of OPMD associated with BQ abuse, dependence, and BUD were 16.3, 18.7, and 9.6-35.5, respectively. The risk of oral cancer for mild, moderate, and severe BUD was 8.5, 8.2, and 42.3, respectively.BUD mediates the link between BQ use and an increased risk of oral malignant disorders. Addressing and treating BQ addiction is an important component of comprehensive OPMD and oral cancer preventive and intervention programs that go beyond simple cessation efforts.© 2024 John Wiley & Sons Ltd.