肥胖引起的代谢功能障碍会增加患肿瘤的风险，然而，代谢性肥胖表型与前列腺癌（PCa）之间的关系仍不清楚。代谢性肥胖表型这一术语是根据代谢状态和BMI类别引入的。参与者被分为四组：代谢健康非肥胖（MHNO）、代谢健康肥胖（MHO）、代谢不健康非肥胖（MUNO）和代谢不健康肥胖（MUO）。根据年龄、种族、婚姻等进行倾向评分匹配。采用单变量和多变量条件logistic回归分析评估代谢性肥胖表型、代谢危险因素和PCa之间的关系。进行敏感性分析以验证结果的稳健性。对564名PCa患者和1418名健康个体进行倾向评分匹配后，每个病例组和对照组各选择209名。两组基本特征无统计学差异。单变量和多变量条件逻辑回归表明，MHO 和 MUO 个体发生 PCa 的风险高于 MHNO 个体。具体而言，MHO个体发生PCa的风险是MHNO个体的2.166倍（OR=2.166，95%CI：1.133-4.139），MUO个体发生PCa的风险是MHNO个体的2.398倍（OR= 2.398, 95%CI:1.271-4.523)。患有高血糖和甘油三酯升高的个体患 PCa 的风险也较高（高血糖：OR=1.488，95%CI：1.001-2.210；甘油三酯升高：OR=2.292，95%CI：1.419-3.702）。具有超过或等于三个代谢危险因素的患者患 PCa 的风险增加（OR=1.990，95%CI：1.166-3.396）。敏感性分析表明，与 MHNO 个体相比，MUO 个体患 PCa 的风险更高。在这项回顾性研究中，MHO 和 MUO 个体患 PCa 的风险更高。版权所有 © 2024 Wang、Apizi、Qiu、Tao 和 An。

Obesity-induced metabolic dysfunction increases the risk of developing tumors, however, the relationship between metabolic obesity phenotypes and prostate cancer (PCa) remains unclear.The term metabolic obesity phenotypes was introduced based on metabolic status and BMI categories. Participants were categorized into four groups: metabolically healthy nonobesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy nonobesity (MUNO), and metabolically unhealthy obesity (MUO). Propensity score matching was conducted based on age, ethnicity, marriage, etc. Univariate and multivariate conditional logistic regression analyses were used to assess the relationship between metabolic obesity phenotypes, metabolic risk factors, and PCa. Sensitivity analysis was performed to verify the robustness of the results.After propensity score matching among 564 PCa patients and 1418 healthy individuals, 209 were selected for each of the case and control groups. There were no statistically significant differences in the basic characteristics between the two groups. Univariate and multivariate conditional logistic regression suggested that the risk of developing PCa in both MHO and MUO individuals was higher than in MHNO individuals. Specifically, the risk of developing PCa in MHO individuals was 2.166 times higher than in MHNO individuals (OR=2.166, 95%CI: 1.133-4.139), and the risk in MUO individuals was is 2.398 times higher than in MHNO individuals(OR=2.398, 95%CI:1.271-4.523). Individuals with hyperglycemia and elevated triglycerides also had a higher risk of developing PCa (hyperglycemia:OR=1.488, 95%CI: 1.001-2.210; elevated triglycerides: OR=2.292, 95%CI: 1.419-3.702). Those with more than or equal to three metabolic risk factors had an increased risk of PCa (OR=1.990, 95%CI: 1.166-3.396). Sensitivity analysis indicated an increased risk of PCa in MUO individuals compared to MHNO individuals.In this retrospective study, individuals with MHO and MUO had a higher risk of developing PCa.Copyright © 2024 Wang, Apizi, Qiu, Tao and An.