本回顾性研究的目的是评估 18F-氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描（[18F]FDG PET/CT 参数）在 cN1-cN3 非小细胞肺癌 (NSCLC) 中的价值) 患者。 59 名接受预处理 [18F]FDG PET/CT 的连续 NSCLC 患者纳入本研究，包括几个原发性肿瘤 PET 参数，包括最大和平均标准化摄取值（SUVmax 和 SUVmean）。提取并分析代谢活性肿瘤体积 (MTV) 和总病灶糖酵解 (TLG = MTVxSUVmean)。总生存期定义为从初次诊断到死亡或最后信息的时间。在整个分析组中，有 44 名患者接受了治疗。临床和公制 PET 参数的单变量 Cox 分析显示，MTV 是 OS 的重要预后因素 (p = 0.024)，而 TLG 和治愈性治疗则显示 15 例由于疾病的严重程度而被分类为姑息治疗。显着性趋势 (p < 0.1)。在多变量 Cox 回归（MTV 和治愈性治疗）中，MTV 仍然是一个重要因素 (p = 0.047)。原发肿瘤的代谢肿瘤体积是 cN1-cN3 NSCLC 患者的唯一独立预后因素。© 2024 大波兰癌症中心。

The aim of this retrospective study was to assess the value of 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT parameters in cN1-cN3 non-small cell lung cancer (NSCLC) patients.59 consecutive patients (35 M, 24 F) with NSCLC who underwent pretreatment [18F]FDG PET/CT were enrolled to this study. Several primary tumor PET parameters, including the maximum and mean standardized uptake value (SUVmax and SUVmean), the metabolic active tumor volume (MTV) and the total lesion glycolysis (TLG = MTVxSUVmean), were extracted and analysed. Overall survival was defined as time from primary diagnosis to death or the last info.In the whole analysed group 44 patients underwent curative treatment, while 15, because of the severity of the disease, were classified for palliative treatment. Univariate Cox analysis of clinical and metric PET parameters revealed that MTV was a significant prognostic factor for OS (p = 0.024), while TLG and curative treatment showed a trend for significance (p < 0.1). In multivariate Cox regression (MTV and curative treatment) MTV remained a significant factor (p = 0.047).Metabolic tumor volume of the primary tumor was the only independent prognostic factor for cN1-cN3 NSCLC patients.© 2024 Greater Poland Cancer Centre.