癌症是当今世界的一个主要健康问题。许多盆腔恶性肿瘤患者需要放射治疗。由于骨骼健康丧失而导致的治疗后发病率的研究较少。我们的研究旨在研究印度患者盆腔放疗后骨盆放射治疗对骨骼健康的影响，包括骨矿物质密度和血液参数以及最大变化的时间。包括患有组织学证实的盆腔恶性肿瘤的患者。患有转移、原发性骨肿瘤或未控制的共病的患者被排除在外。患者接受同步放化疗，使用传统的分次外照射放疗，然后根据需要进行近距离放射治疗。放疗前及放疗结束后6周、3个月、6个月测定骨密度T评分、Z评分、血清碱性磷酸酶、维生素D3、磷、钙。 p值≤0.05被认为具有统计学意义。我们发现，放射治疗后三个月，平均Z评分显着下降，平均血清碱性磷酸酶显着上升。这与放射治疗后平均 T 评分、维生素 D3、磷和钙的微小变化有关。未发现骨盆机能不全骨折。印度患者在治疗后三个月，碱性磷酸酶升高，Z 评分在放射治疗后显着下降。这表明治疗后三个月骨转换达到最大。必要时，可考虑通过仔细监测患者此时进行药物干预。© 2024 大波兰癌症中心。

Cancer is a major health problem in today's world. Many patients of pelvic malignancies need treatment by radiation therapy. Post-treatment morbidity due to loss of bone health is less commonly studied. Our study aims at studying the impact of pelvic radiation therapy on bone health including bone mineral density and blood parameters and time of maximum change in Indian patients after pelvic radiotherapy.Patients suffering from histologically confirmed pelvic malignancies were included. Patients having metastasis, primary bone tumor or uncontrolled co-morbid conditions were excluded. Patients were treated with concomitant chemoradiation using conventional fractionation of external beam radiotherapy followed by brachytherapy where indicated. T score and Z score of bone mineral density, serum alkaline phosphatase, vitamin D3, phosphorus and calcium were measured before radiation therapy and 6 weeks, three months, and six months after completion of radiation therapy. A p-value ≤ 0.05 was considered statistically significant.We found that there was a significant decrease in mean Z score and a significant rise of mean serum alkaline phosphatase at three months post radiation therapy. This was associated with an insignificant changes of mean T score, vitamin D3, phosphorus and calcium after radiation therapy. No pelvic insufficiency fractures were detected.In Indian patients, alkaline phosphatase rises, and Z score falls significantly after radiation therapy at three months after treatment. This suggests maximum bone turnover at three months after treatment. Pharmacological intervention, when necessary, may be considered by careful monitoring of patients by this time.© 2024 Greater Poland Cancer Centre.