由于骨相关事件，肺癌骨转移（BMLC）严重降低了患者的生活质量，并且全球范围内缺乏有关内科和手术治疗的明确指南，显着降低了患者的生存率。尽管过去二十年来关于BMLC的知识呈指数级增长，但全面、客观的文献计量分析仍然缺乏。通过Biblioshiny、VOSviewer、Scimago从Web of Science数据库中提取2004年至2023年有关BMLC的相关文献，进行了全面的文献计量分析Graphica、CiteSpace 和 Microsoft Office Excel Professional Plus 2016 软件。从 Web of Science 核心合集 (WoSCC) 中提取了 936 篇与 BMLC 相关的论文。然后将出版物、国家、机构、全球合作、作者、期刊、关键词、主题趋势和引用的参考文献的数量可视化。最后对近20年的研究现状和发展方向进行了分析。本研究共收录了2004年至2023年BMLC上的论文936篇。全球发表论文数量逐年稳步增长，于2021年达到顶峰。出版物数量最多，其次是日本和美国。此外，中国的引用次数最多，H 指数为 35，美国紧随其后，H 指数为 34，凸显了他们对该领域的重大贡献。 《肿瘤学前沿》的出版物数量最多。 CiteSpace 分析将“肺癌”、“骨转移”和“生存”列为高频关键词，概括了核心研究热点。关键词聚类分析揭示了代表主要研究方向的六个主要聚类。关键词爆发分析显示，“骨骼并发症”在2005年至2013年期间爆发强度最高，近期研究趋势包括“免疫治疗”和“狄诺塞麦”，在2021年至2023年期间爆发。趋势主题分析表明，“非小细胞” “肺癌”、“免疫治疗”、“免疫检查点抑制剂”代表了该领域的前沿研究方向。本文揭示了全球范围内不断增加的BMLC研究现状和趋势。中美两国贡献最大，但BMLC国际合作研究应加强。 BMLC的发病机制、早期预防和个体化治疗有待加强进一步研究，免疫治疗是肺癌骨转移研究的下一个热点。Copyright © 2024 Tang, Gu, Yang, Ma, Liu, Shi, Niu, Wang 。

Bone metastases of lung cancer (BMLC) severely diminish patients' quality of life due to bone-related events, and the lack of clear guidelines globally regarding medical and surgical treatment significantly reduces patient survival. While knowledge about BMLC has grown exponentially over the past two decades, a comprehensive and objective bibliometric analysis remains absent.A comprehensive bibliometric analysis was conducted on relevant literature on BMLC extracted from the Web of Science database from 2004 to 2023 by Biblioshiny, VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Office Excel Professional Plus 2016 software. 936 papers related to BMLC were extracted from the Web of Science Core Collection (WoSCC). The number of publications, countries, institutions, global collaborations, authors, journals, keywords, thematic trends, and cited references were then visualized. Finally, the research status and development direction in the last 20 years were analyzed.This study included a total of 936 papers on BMLC from 2004 to 2023. There has been a steady increase in global publications each year, peaking in 2021. China had the highest number of publications, followed by Japan and the United States. Additionally, China had the most citations with an H-index of 35, while the US followed with an H-index of 34, highlighting their significant contributions to the field. "Frontiers in Oncology" had the highest number of publications. CiteSpace analysis identified "lung cancer," "bone metastasis," and "survival" as the top high-frequency keywords, encapsulating the core research focus. Keyword clustering analysis revealed six main clusters representing the primary research directions. Burst analysis of keywords showed that "skeletal complications" had the highest burst intensity from 2005 to 2013, while recent research trends include "immunotherapy" and "denosumab," with bursts from 2021 to 2023. Trend topic analysis indicated that "non-small cell lung cancer," "immunotherapy," and "immune checkpoint inhibitors" represent the cutting-edge research directions in this field.This article reveals the current status and trend of research on BMLC, which is increasing worldwide. China and the United States have contributed the most, but international cooperative research on BMLC should be strengthened. The pathogenesis, early prevention, and individualized treatment of BMLC need to be strengthened for further study, and immunotherapy is the next hotspot of lung cancer bone metastasis research.Copyright © 2024 Tang, Gu, Yang, Ma, Liu, Shi, Niu and Wang.