之前我们已经确定癌基因和抑癌基因的表达数量和水平与癌细胞的主要细胞进展高度正相关或负相关。然而，我们尚未在整体基因表达水平上定义人类肿瘤细胞的任何细胞潜力。在这里，我们深入计算了表达基因的总数和mRNA的总数，发现mRNA的表达水平与人类肿瘤细胞中基因的表达数量直接相关。基因表达网络揭示了三羧酸 (TCA) 循环和 ATP 生成的稳态、可能受到不确定基因表达网络干扰和阻断的分化潜力，以及经历上皮间质转化 (EMT)、神经发生、血管生成、炎症反应的潜在能力、免疫逃避和人类肿瘤细胞的转移。我们的分析确定了人类肿瘤细胞中不可预测的基因表达特征。这些结果可能会深刻影响人类肿瘤细胞生成和发展的机制。© 2024 作者。

Previously we have identified that the expression number and levels of oncogenes and antioncogenes are highly positively or negatively associated with major cellular progress in a cancer cell. However, we have not defined any cellular potentials of a human tumor cell at the level of the overall gene expression. Here, we counted the overall number of expression genes and overall counts of mRNA in depth and revealed that the expression levels of mRNA were directly associated with the expression number of genes in a human tumor cell. Gene expression networks revealed steady states of tricarboxylic acid (TCA) cycle and ATP production, differentiation potentials that might be disturbed and blocked by uncertain gene expressing networks, and potential capabilities to undergo epithelial-mesenchymal transition (EMT), neurogenesis, angiogenesis, inflammatory response, immune evasion, and metastasis in a human tumor cell. Our analysis identifies unpredictable gene expression characteristics in human tumor cells. The results might profoundly influence mechanisms how a human tumor cell generates and undergoes its progresses.© 2024 The Authors.