作为最常见的内分泌癌症，甲状腺癌（TC）在过去三十年中在全球范围内急剧增加。 TC 发病率的增加可能与遗传、辐射、碘、自身免疫性疾病和环境内分泌干扰化学物质 (EDC) 接触有关。多溴二苯醚 (PBDE) 是典型的 EDC，自 20 世纪 80 年代以来已作为阻燃剂广泛应用于塑料、电子、家具和纺织品中，研究表明其暴露与 TC 风险之间存在显着相关性。即便如此，PBDE 暴露对 TC 代谢特征的影响仍有待探索。在这项研究中，基于病例对照流行病学，使用气相色谱-大气压化学电离-串联质谱法 (GC-APCI-MS) 测定了 111 名甲状腺乳头状癌 (PTC) 患者和 111 名健康参与者的血清中的 PBDE 八种同系物。 /多发性硬化症）。根据 59 名参与者的总 PBDE 浓度的三分位分布，通过超高效液相色谱与混合四极杆 Orbitrap MS 联用进一步进行代谢组学分析。在偏相关分析中，29种鉴定的代谢物与PBDEs暴露量相关（P<0.05）。此外，PBDEs破坏了甘油磷脂、鞘脂、牛磺酸和亚牛磺酸的代谢，表明神经递质、氧化应激和炎症是PTC中受影响的脆弱途径。此外，(±)-章鱼胺和 5-羟基吲哚（两者均可调节神经递质的作用）在接触 PBDE 后成为 TC 潜在的代谢紊乱标记物。本研究从代谢变化的角度分析了PBDEs对PTC的影响，并进一步探讨了可能的生物标志物，帮助我们深入了解PBDEs对TC影响的可能机制。©2024。作者。

As the most common endocrine cancer, thyroid cancer (TC) has sharply increased globally over the past three decades. The growing incidence of TC might be counted by genetics, radiation, iodine, autoimmune disease, and exposure to environmental endocrine-disrupting chemicals (EDCs). Polybrominated diphenyl ethers (PBDEs), being typical EDCs, have been widely utilized in plastics, electronics, furniture, and textiles as flame retardants since the 1980s, and research has indicated a significant correlation between their exposure and the risk of TC. Even so, PBDEs exposure impact on the metabolic signature for TC remains unexplored. In this study, eight congeners of PBDEs were determined in serum from 111 patents with papillary thyroid cancer (PTC) and 111 healthy participants based on case-control epidemiology using gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (GC-APCI-MS/MS). Based on the tertile distribution of total PBDEs concentrations in 59 participants, metabolomics analysis was further performed by ultra-high performance liquid chromatography coupled to hybrid quadrupole-Orbitrap MS. In the partial correlation analysis, the 29 identified metabolites were correlated with PBDEs exposure (P < 0.05). In addition, PBDEs disrupted the metabolism of glycerophospholipids, sphingolipids, taurine, and hypotaurine, indicating that neurotransmitters, oxidative stress, and inflammation are the vulnerable pathways affected in PTC. Furthermore, (±)-octopamine and 5-hydroxyindole, both of which modulate the actions of neurotransmitters, emerged as potential disturbed metabolite markers for TC following exposure to PBDEs. This study analyzed the impact of PBDEs on PTC in terms of the metabolic changes and further explored possible biomarkers, which helped us have a deep understanding of the possible mechanism of the effects of PBDEs on TC.© 2024. The Author(s).