微藻是一类含有叶绿素A、光合作用强、营养丰富的微生物。它们可以生产用于生物医学应用的多种生物活性物质（肽、蛋白质、多糖和脂肪酸）。尽管微藻生物治疗具有独特的优势，但治疗效率不足限制了其进一步应用。随着纳米技术的发展，微藻与生物材料的结合可以提高治疗效果，越来越受到人们的关注。在这种微藻-生物材料混合系统中，具有优异光学和磁性能的生物材料在生物治疗中发挥着重要作用。微藻作为天然载体，可以增加含氧量，缓解病变部位缺氧，进一步增强治疗效果。本综述全面总结了微藻-生物材料混合系统在不同疾病（癌症、心肌梗塞、缺血性中风、慢性感染和肠道疾病）中的协同治疗作用。© 2024 Wiley‐VCH GmbH。

Microalgae are a group of microorganisms containing chlorophyll A, which are highly photosynthetic and rich in nutrients. And they can produce multiple bioactive substances (peptides, proteins, polysaccharides, and fatty acids) for biomedical applications. Despite the unique advantages of microalgae-based biotherapy, the insufficient treatment efficiency limits its further application. With the development of nanotechnology, the combination of microalgae and biomaterials can improve therapeutic efficacies, which has attracted increasing attention. In this microalgal-biomaterials hybrid system, biomaterials with excellent optical and magnetic properties play an important role in biological therapy. Microalgae, as a natural vehicle, can increase oxygen content and alleviate hypoxia in diseased areas, further enhancing therapeutic effects. In this review, the synergistic therapeutic effects of microalgal-biomaterials hybrid system in different diseases (cancer, myocardial infarction, ischemia stroke, chronic infection, and intestinal diseases) are comprehensively summarized.© 2024 Wiley‐VCH GmbH.