免疫和组织稳态是通过平衡调节细胞存活、增殖和细胞死亡的信号来实现的。最近的研究表明，某些细胞死亡程序可以刺激炎症，通常被称为“免疫原性细胞死亡”（ICD）。 ICD 是一把双刃剑，可以提供针对病原体感染的保护，但也会造成组织损伤。坏死性凋亡是一个关键的 ICD 模块，已被证明参与宿主防御病原体感染、组织稳态和癌症对免疫治疗的反应。在这里，我们将回顾有关坏死性凋亡信号调节及其在病原体感染、组织稳态和癌症中的作用的最新发现。版权所有 © 2024 Elsevier Ltd。保留所有权利。

Immune and tissue homeostasis is achieved through balancing signals that regulate cell survival, proliferation, and cell death. Recent studies indicate that certain cell death programs can stimulate inflammation and are often referred as 'immunogenic cell death' (ICD). ICD is a double-edged sword that can confer protection against pathogen infection but also cause tissue damage. Necroptosis is a key ICD module that has been shown to participate in host defense against pathogen infection, tissue homeostasis, and cancer response to immunotherapy. Here, we will review recent findings on the regulation of necroptosis signaling and its role in pathogen infection, tissue homeostasis, and cancer.Copyright © 2024 Elsevier Ltd. All rights reserved.