通过雾化进行肺部药物输送是一种实现局部和全身效应的非侵入性方法。本研究的目的是使用各种脂质制剂（包括脂质体 (F1-F3)、传递体 (F4-F6)、胶束 (F7) 确定粘度作为一个新方面（即低、中和高）的影响。 -F9）和纳米结构脂质载体（NLC；F10-F12）），并使用反式白藜芦醇（TRES）作为模型抗癌药物研究它们对体外雾化性能的影响。根据理化性质，胶束（F7-F9）具有最小的粒径（12-174nm）；此外，所有测试的制剂均表现出高包封率（>89%）。通过毛细管粘度计测量，NLC配方表现出最高的粘度（3.35-10.04m2/sec）。使用旋转流变仪后，配方表现出剪切稀化（非牛顿）行为。随后采用空气喷射和振动网雾化器通过体外模型评估雾化性能。较高粘度的制剂会导致雾化时间延长。振动网雾化器表现出显着更高的发射剂量 (ED)、细颗粒分数 (FPF) 和细颗粒剂量 (FPD)（高达 97%、90% 和 64μg）。此外，TRES 的体外释放在 pH 5 时较高，表明释放曲线与 Korsmeyer-Peppas 模型一致。因此，具有较高粘度的制剂与振动网状雾化器搭配是输送和靶向外周肺的理想组合。版权所有 © 2024。由 Elsevier B.V. 出版。

Pulmonary drug delivery via aerosolization is a non-intrusive method for achieving localized and systemic effects. The aim of this study was to establish the impact of viscosity as a novel aspect (i.e., low, medium and high) using various lipid-based formulations (including liposomes (F1-F3), transfersomes (F4-F6), micelles (F7-F9) and nanostructured lipid carriers (NLCs; F10-F12)) as well as to investigate their impact on in-vitro nebulization performance using Trans-resveratrol (TRES) as a model anticancer drug. Based on the physicochemical properties, micelles (F7-F9) elicited the smallest particle size (12-174 nm); additionally, all formulations tested exhibited high entrapment efficiency (>89 %). Through measurement using capillary viscometers, NLC formulations exhibited the highest viscosity (3.35-10.04 m2/sec). Upon using a rotational rheometer, formulations exhibited shear-thinning (non-Newtonian) behaviour. Air jet and vibrating mesh nebulizers were subsequently employed to assess nebulization performance using an in-vitro model. Higher viscosity formulations elicited a prolonged nebulization time. The vibrating mesh nebulizer exhibited significantly higher emitted dose (ED), fine particle fraction (FPF) and fine particle dose (FPD) (up to 97 %, 90 % and 64 µg). Moreover, the in-vitro release of TRES was higher at pH 5, demonstrating an alignment of the release profile with the Korsmeyer-Peppas model. Thus, formulations with higher viscosity paired with a vibrating mesh nebulizer were an ideal combination for delivering and targeting peripheral lungs.Copyright © 2024. Published by Elsevier B.V.