多形性胶质母细胞瘤（GBM）是一种高度严重的原发性脑肿瘤。尽管进行了广泛的研究，但有效的治疗方法仍然难以捉摸。长非编码 RNA (lncRNA) 在癌症和正常生物学中发挥着重要作用。它们影响选择性剪接（AS），这对于癌症至关重要。 lncRNA 特异性微阵列和下一代测序的进步增强了对 AS 的理解。异常的 AS 会导致癌症侵袭、转移、细胞凋亡、治疗耐药和肿瘤发展，包括神经胶质瘤。 lncRNA介导的AS影响多种细胞信号传导途径，促进或抑制癌症恶性肿瘤。本综述讨论了胶质母细胞瘤中调节 AS 的 lncRNA 及其机制。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

Glioblastoma multiforme (GBM) is a highly severe primary brain tumor. Despite extensive research, effective treatments remain elusive. Long noncoding RNAs (lncRNAs) play a significant role in both cancer and normal biology. They influence alternative splicing (AS), which is crucial in cancer. Advances in lncRNA-specific microarrays and next-generation sequencing have enhanced understanding of AS. Abnormal AS contributes to cancer invasion, metastasis, apoptosis, therapeutic resistance, and tumor development, including glioma. lncRNA-mediated AS affects several cellular signaling pathways, promoting or suppressing cancer malignancy. This review discusses the lncRNAs regulating AS in glioblastoma and their mechanisms.Copyright © 2024 Elsevier Ltd. All rights reserved.