咖啡是一种普遍饮用的饮料，已知含有数千种生物活性成分，这些成分因其对包括阿尔茨海默病 (AD) 在内的各种神经退行性疾病具有潜在的神经保护作用而引起人们的兴趣。人们对咖啡因、葫芦巴碱、绿原酸和咖啡酸等咖啡成分进行了广泛的研究，重点关注它们的神经保护特性。这些化合物有可能影响 AD 发展的关键机制，包括淀粉样蛋白病、tau 蛋白病和神经炎症。此外，除了其神经保护作用外，饮用咖啡还具有抗癌和抗炎作用，从而增强了其治疗潜力。研究表明，适量摄入咖啡（通常每天大约两到三杯）可能有助于缓解 AD 进展并降低相关神经系统疾病的风险。该文献强调了咖啡化合物的潜在神经保护特性，这些化合物通常通过调节活化 B 细胞的核因子 kappa 轻链增强子 (NF-κB)、核因子红细胞衍生 2 样 2 (Nrf2 )、白细胞介素、肿瘤坏死因子-α (TNF-α) 和许多其他分子。版权所有 © 2024 Elsevier B.V. 保留所有权利，包括文本和数据挖掘、人工智能培训和类似技术的权利。

Coffee, a universally consumed beverage, is known to contain thousands of bioactive constituents that have garnered interest due to their potential neuroprotective effects against various neurodegenerative disorders, including Alzheimer's disease (AD). Extensive research has been conducted on coffee constituents such as Caffeine, Trigonelline, Chlorogenic acid, and Caffeic acid, focusing on their neuroprotective properties. These compounds have potential to impact key mechanisms in AD development, including amyloidopathy, tauopathy, and neuroinflammation. Furthermore, apart from its neuroprotective effects, coffee consumption has been associated with anticancerogenic and anti-inflammatory effects, thereby enhancing its therapeutic potential. Studies suggest that moderate coffee intake, typically around two to three cups daily, could potentially contribute to mitigating AD progression and lowering the risk of related neurological disorders. This literature underscores the potential neuroprotective properties of coffee compounds, which usually perform their neuronal protective effects via modulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), nuclear factor erythroid-derived 2-like 2 (Nrf2), interleukins, tumor necrosis factor-alpha (TNF-α), and many other molecules.Copyright © 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.