SAGA 复合体是一种进化上保守的组蛋白乙酰转移酶复合体，也是发育和疾病所必需的转录共激活因子。 SAGA 失调与多种人类疾病有关，包括癌症。在本期《基因》中

The SAGA complex is an evolutionarily conserved histone acetyltransferase complex and transcription coactivator essential for development and disease. Dysregulation of SAGA is implicated in various human diseases, including cancer. In this issue of Genes & Development, Chen et al. (doi/10.1101/gad.351789.124) uncover a critical role for SAGA in multiple myeloma wherein SAGA's ADA2B component is required for the expression of mTORC1 pathway genes and targets of the MYC, E2F, and MAF (musculoaponeurotic fibrosarcoma) transcription factors. SAGA cooperates with MYC and MAF to sustain oncogenic gene expression programs vital for multiple myeloma survival and thus may serve as a therapeutic target for future cancer therapies.© 2024 Wang et al.; Published by Cold Spring Harbor Laboratory Press.