环状 RNA (circRNA) 是独特的非编码 RNA，具有通过反向剪接生成的闭合且稳定的环结构。由于其保守性、稳定性和组织特异性，circRNA 有可能用作某些肿瘤的诊断指标和治疗靶点。许多研究表明，circRNA可以作为微小RNA（miRNA）海绵，与蛋白质和翻译模板相互作用，调节基因表达和信号转导，从而参与多种恶性肿瘤的发生和发展。免疫疗法彻底改变了癌症的治疗。早期研究表明circRNA参与调节肿瘤免疫微环境和抗肿瘤免疫。 CircRNA 可能有潜力成为提高免疫治疗敏感性和扩大受益于癌症免疫治疗的患者群体的重要靶标。然而，很少有研究探讨circRNA与肿瘤免疫之间的相关性。在这篇综述中，我们总结了目前有关通过不同机制参与抗肿瘤免疫调节的circRNA的研究及其在提高免疫治疗疗效方面的潜在价值，旨在为癌症免疫治疗提供新的靶点。© 2024。作者。

Circular RNAs (circRNAs) are unique noncoding RNAs that have a closed and stable loop structure generated through backsplicing. Due to their conservation, stability and tissue specificity, circRNAs can potentially be used as diagnostic indicators and therapeutic targets for certain tumors. Many studies have shown that circRNAs can act as microRNA (miRNA) sponges, and engage in interactions with proteins and translation templates to regulate gene expression and signal transduction, thereby participating in the occurrence and development of a variety of malignant tumors. Immunotherapy has revolutionized the treatment of cancer. Early researches have indicated that circRNAs are involved in regulating tumor immune microenvironment and antitumor immunity. CircRNAs may have the potential to be important targets for increasing sensitivity to immunotherapy and expanding the population of patients who benefit from cancer immunotherapy. However, few studies have investigated the correlation between circRNAs and tumor immunity. In this review, we summarize the current researches on circRNAs involved in antitumor immune regulation through different mechanisms and their potential value in increasing immunotherapy efficacy with the goal of providing new targets for cancer immunotherapy.© 2024. The Author(s).